Invitrogen

GDAP1 Polyclonal Antibody

GDAP1 Antibody in Immunocytochemistry (ICC/IF)

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GDAP1 Antibody (PA5-53136) in ICC/IF

Immunofluorecent analysis of GDAP1 in human cell line A549 using GDAP1 Polyclonal Antibody (Product # PA5-53136). Staining shows localization to cytosol and mitochondria.

GDAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GDAP1 Antibody in Immunohistochemistry (IHC)

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GDAP1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of GDAP1 demonstrates antibody specificity. Immunohistochemical analysis of GDAP1 using anti-GDAP1 Polyclonal Antibody (Product # PA5-53136), shows significant staining of GDAP1 in human cerebral cortex and shows minimal or weak staining in human pancreas tissues. The relative expression levels of GDAP1 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-53136

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human GDAP1. Recombinant protein control fragment (Product #RP-90927).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2641932

产品详细信息

Immunogen sequence: PLSEHNEPWF MRLNSTGEVP VLIHGENIIC EATQIIDYLE QTFLDERTPR LMPDKESMYY

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 97%.

靶标信息

Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 (ganglioside-induced differentiation-associated protein 1) is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。