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GDF6 Antibody (PA5-78681) in IHC (P)
GDF6 Polyclonal Antibody detects GDF6 protein at cytoplasm in rat brain by immunohistochemical analysis. Sample: Paraffin-embedded rat brain. GDF6 Polyclonal Antibody (Product # PA5-78681) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-78681
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human GDF6. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.76 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2735828
产品详细信息
Positive Control: U87-MG
Predicted Reactivity: Mouse (91%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP-13; Bone morphogenetic protein 13; GDF-6; growth differentiation factor 16; Growth/differentiation factor 16; Growth/differentiation factor 6; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome
基因别名: BMP-13; BMP13; CDMP2; GDF16; GDF6; KFM; KFS; KFS1; KFSL; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
UniProt ID: (Human) Q6KF10, (Rat) Q6HA10
Entrez Gene ID: (Human) 392255, (Rat) 252834
apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
positive regulation of chondrocyte differentiation
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
cell development
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
positive regulation of p38MAPK cascade
retinal cell apoptotic process
