Invitrogen

GNAO1 Polyclonal Antibody

GNAO1 Antibody in Immunohistochemistry (IHC)

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GNAO1 Antibody (PA5-59337) in IHC

Immunohistochemical staining of GNAO1 in human cerebral cortex and pancreas tissues using GNAO1 Polyclonal Antibody (Product # PA5-59337). Corresponding GNAO1 RNA-seq data are presented for the same tissues.

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GNAO1 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell and tissues owing to their inherent genetic constitution. Relative expression of GNAO1 was observed in IMR-32 and Mouse Brain in comparison to Mouse Lung, Mouse Kidney and Mouse Skeletal Muscle using GNAO1 Polyclonal Antibody product (Product # PA5-59337) in western blot. {RE}

产品信息

PA5-59337

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:500-1:1,000

免疫组化（冰冻） (IHC (F))

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产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human GNAO1. Recombinant protein control fragment (Product #RP-102901).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2642080

产品详细信息

Immunogen sequence: IQSLAAIVRA MDTLGIEYGD KERKADAKMV CDVVSRMEDT EPFSAELLSA MMRLWGDSGI QECF

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.

靶标信息

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.

Development (Cambridge, England)

Katreddi RR,Taroc EZM,Hicks SM,Lin JM,Liu S,Xiang M,Forni PE

PA5-59337 was used in Immunocytochemistry-immunoflourescence to indicate that Notch signaling plays a pivotal role in triggering the binary differentiation dichotomy in the VNO of rodents.

Fri Jul 01 00:00:00 UTC 2022

Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.

Development (Cambridge, England)

Katreddi RR,Taroc EZM,Hicks SM,Lin JM,Liu S,Xiang M,Forni PE

PA5-59337 was used in Immunocytochemistry-immunoflourescence to indicate that Notch signaling plays a pivotal role in triggering the binary differentiation dichotomy in the VNO of rodents.

Fri Jul 01 00:00:00 UTC 2022

Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons.

eLife

Lin JM,Mitchell TA,Rothstein M,Pehl A,Taroc EZM,Katreddi RR,Parra KE,Zuloaga DG,Simoes-Costa M,Forni PE

PA5-59337 was used in Immunohistochemistry to suggest that the transcription factor Tfap2e can reprogram vomeronasal sensory neurons bypassing cellular plasticity restrictions, and that it directly controls the expression of batteries of vomeronasal genes.

Fri Sep 16 00:00:00 UTC 2022

生物信息学

蛋白别名: DKFZp686O0962; G alpha o; GNAO 1; GO2-q chimeric G-protein; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2

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基因别名: EIEE17; G-ALPHA-o; GNAO; GNAO1; HLA-DQB1

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UniProt ID: (Human) P09471

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Entrez Gene ID: (Human) 2775

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功能