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产品信息
PA5-82736
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2789892
产品详细信息
Immunogen sequence: HALELLVIRN YGPEVWEDIK KEAQLDEEGQ FLVRIIYDDS KTYDLVAAAS KVLNLNAGEI LQMFGKMFFV FCQESGYDTI LRVLGSNVRE FLQNLDALHD HLATIYPGMR APSFRCTDAE KGKGLILHYY SEREGLQDIV IGII
靶标信息
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
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生物信息学
蛋白别名: GCS beta1; GCS beta3; GCS-beta-1; GCS-beta-3; GCS-beta1; GCS-beta3; GCSbeta1; GCSbeta3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit
基因别名: GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3
UniProt ID: (Human) Q02153
Entrez Gene ID: (Human) 2983
