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Glutaredoxin 2 Antibody (PA5-79316) in IHC (P)
Immunohistochemical analysis of Glutaredoxin 2 in paraffin-embedded section of human mammary cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-Glutaredoxin 2 antibody (Product # PA5-79316) overnight at 4°C. Biotinylated ... View More
产品信息
PA5-79316
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human Glutaredoxin 2 (103-119aa EYGNQFQDALYKMTGER).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746432
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First discovered in E. coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kD dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); glutaredoxin (thioltransferase) 2; glutaredoxin 2 (thioltransferase); Glutaredoxin-2, mitochondrial
基因别名: 1700010P22Rik; AI645710; CGI-133; GLRX2; GRX2
UniProt ID: (Human) Q9NS18, (Mouse) Q923X4, (Rat) Q6AXW1
Entrez Gene ID: (Human) 51022, (Mouse) 69367, (Rat) 114022
transport
response to organic substance
response to hydrogen peroxide
cell redox homeostasis
oxidation-reduction process
aging
cellular response to superoxide
regulation of transcription, DNA-templated
glutathione metabolic process
apoptotic process
response to temperature stimulus
regulation of signal transduction
cell differentiation
DNA protection
response to redox state
