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H2A.Zac pan-acetyl (K4,K7,K11) Antibody (PA5-40095) in ChIP-seq
ChIP was performed with 1 µg of Acetyl-Histone H2A.Z (Lys4 + Lys7 +Lys11) polyclonal antibody (Product # PA5-40095) on sheared chromatin from 1 million HeLaS3 cells. IgG (2 µg/IP) was used as a negative IP control. The IP'd DNA was analyzed by QPCR. The IP'd DNA was subsequently analyzed with a Genome Analyzer. The 36 bp tags were aligned to the human genome using the ELAND algorithm. Figure 2 shows the pea... View More
产品信息
PA5-40095
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide corresponding to human histone H2A.Z acetylated at lysines 4, 7, and 11.
偶联物
形式
Liquid
浓度
1.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.05% sodium azide, 0.05% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609565
靶标信息
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 11ac; Acetyl-Histone H2A.Z K4 K7 K11; Acetyl-Histone H2A.Z Lys4 Lys7 Lys11; H2A histone family, member V; H2A histone family, member Z; H2A.F/Z; H2A.Z variant histone 2; H2A.ZK4,7,11ac; H2A.ZK5; H2A.ZK5ac; H2A.ZLys4,7,11ac; H2A/z; H2AFZac; H2AZ histone; H2AZK11ac; H2AZK4,7,11ac; H2AZK7ac; H2AZLys4,7,11ac; histone H2A.F/Z; Histone H2A.V; Histone H2A.Z; purine-rich binding element protein B
基因别名: H2A.z; H2A.Z-1; H2A.Z-2; H2A/z; H2AFV; H2AFZ; H2AV; H2AZ; H2AZ1; H2AZ2
UniProt ID: (Human) Q71UI9, (Human) P0C0S5
Entrez Gene ID: (Human) 94239, (Human) 3015
molecular_function
DNA binding
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
protein binding
chromatin DNA binding
nucleosomal DNA binding
histone
