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HARS Antibody (PA5-106468) in ICC/IF
Immunofluorescent analysis of HARS in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with HARS polyclonal antibody (Product # PA5-106468) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
产品信息
PA5-106468
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HARS(Accession P12081), corresponding to amino acid residues K472-C509.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854137
产品详细信息
Antibody detects endogenous levels of total HARS.
靶标信息
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dead end homolog 1; FLJ20491; HisRS; histidine translase; histidine tRNA ligase; Histidine--tRNA ligase, cytoplasmic; Histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic
基因别名: CMT2W; Dnd1; HARS; HARS1; HRS; MMHRS; USH3B
UniProt ID: (Human) P12081, (Mouse) Q61035
Entrez Gene ID: (Human) 3035, (Mouse) 15115, (Rat) 307492
