Rockland

HDAC2 (near C-terminus) Polyclonal Antibody

查看其他24个HDAC2抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

600-401-J18

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000
-

免疫组化 (IHC)

1:100-1:500
-

酶联免疫吸附实验 (ELISA)

1:20,000-1:60,000
-

免疫沉淀 (IP)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

HDAC2 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the near C-terminal region of human HDAC2.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

0.02M potassium phosphate, pH 7.2, with 30% glycerol, 0.15M NaCl

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This antibody is specific towards HDAC2. A BLAST analysis was used to suggest cross-reactivity with Human, Mouse, Rat, and Primate based on 100% sequence homology. Cross-reactivity with HDAC2 from other sources has not been determined.

靶标信息

HDAC2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: HD2; hdac 2; hdac-2; Histone deacetylase 2; Protein deacylase HDAC2; transcriptional regulator homolog RPD3; YY1 transcription factor-binding protein; YY1-associated factor 1

查看更多 收起

基因别名: D10Wsu179e; HD2; HDAC2; mRPD3; RPD3; YAF1; Yy1bp

查看更多 收起

UniProt ID: (Human) Q92769, (Mouse) P70288

查看更多 收起

Entrez Gene ID: (Human) 3066, (Mouse) 15182, (Rat) 84577

查看更多 收起

功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter binding RNA polymerase II repressing transcription factor binding chromatin binding histone deacetylase activity protein binding transcription factor binding deacetylase activity enzyme binding heat shock protein binding nucleosomal DNA binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity sequence-specific DNA binding poly(A) RNA binding NF-kappaB binding transcription factor activity, sequence-specific DNA binding hydrolase activity histone deacetylase activity (H3-K14 specific) chromatin DNA binding histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) Krueppel-associated box domain binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific)
参与通路
negative regulation of transcription from RNA polymerase II promoter response to amphetamine cardiac muscle hypertrophy chromatin remodeling maintenance of chromatin silencing transcription, DNA-templated blood coagulation positive regulation of cell proliferation epidermal cell differentiation positive regulation of epithelial to mesenchymal transition positive regulation of receptor biosynthetic process negative regulation of neuron projection development dendrite development histone deacetylation response to caffeine response to lipopolysaccharide positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production circadian regulation of gene expression positive regulation of collagen biosynthetic process cellular response to heat response to nicotine response to cocaine odontogenesis of dentin-containing tooth response to drug positive regulation of tyrosine phosphorylation of Stat3 protein embryonic digit morphogenesis ATP-dependent chromatin remodeling negative regulation of apoptotic process negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of MHC class II biosynthetic process positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter behavioral response to ethanol positive regulation of oligodendrocyte differentiation response to hyperoxia hair follicle placode formation negative regulation of dendritic spine development eyelid development in camera-type eye fungiform papilla formation cellular response to hydrogen peroxide histone H3 deacetylation histone H4 deacetylation cellular response to retinoic acid cellular response to transforming growth factor beta stimulus regulation of signal transduction by p53 class mediator cellular response to dopamine negative regulation of peptidyl-lysine acetylation regulation of transcription, DNA-templated protein deacetylation chromatin modification hippocampus development neuron differentiation rhythmic process positive regulation of sequence-specific DNA binding transcription factor activity regulation of protein kinase B signaling cardiac muscle cell development negative regulation of cardiac muscle cell proliferation regulation of sarcomere organization negative regulation of canonical Wnt signaling pathway regulation of protein deacetylation negative regulation of intrinsic apoptotic signaling pathway histone H3-K9 modification
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持