Invitrogen

HEY1 Polyclonal Antibody

HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HEY1 Antibody (PA5-40553) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human kidney tissue using an anti-HEY1 polyclonal antibody (Product # PA5-40553).

HEY1 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

HEY1 Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-40553

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

4-8 µg/mL

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the C-terminal of human HEY1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2576326

产品详细信息

Peptide sequence: PQNGHGNAGT TASPTEPHHQ GRLGSAHPEA PALRAPPSGS FGPVLPVVTS

Sequence homology: Cow: 79%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 79%; Rat: 93%

靶标信息

Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Crosstalk between Androgen-ZIP9 Signaling and Notch Pathway in Rodent Sertoli Cells.

International journal of molecular sciences

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Bilinska B,Hejmej A

Published figure using HEY1 polyclonal antibody (Product # PA5-40553) in Immunocytochemistry

Thu Nov 05 00:00:00 UTC 2020

Crosstalk between Androgen-ZIP9 Signaling and Notch Pathway in Rodent Sertoli Cells.

International journal of molecular sciences

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Bilinska B,Hejmej A

Published figure using HEY1 polyclonal antibody (Product # PA5-40553) in Immunocytochemistry

Thu Nov 05 00:00:00 UTC 2020

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

PA5-40553 was used in Immunohistochemistry to examine whether activation of Notch receptors and expression of Notch ligands and effector genes in rat seminiferous epithelium are controlled by androgen signaling during puberty.

Thu Apr 16 00:00:00 UTC 2020

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

Thu Apr 16 00:00:00 UTC 2020

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

Thu Apr 16 00:00:00 UTC 2020

Notch signaling regulates nuclear androgen receptor AR and membrane androgen receptor ZIP9 in mouse Sertoli cells.

Andrology

Kamińska A,Pardyak L,Marek S,Wróbel K,Kotula-Balak M,Bilińska B,Hejmej A

PA5-40553 was used in Immunohistochemistry (Paraffin), Western Blot to demonstrate that AR expression is regulated by DLL1-mediated Notch signaling, whereas JAG1 is involved in the regulation of ZIP9.

Sun Mar 01 00:00:00 UTC 2020

Notch signaling regulates nuclear androgen receptor AR and membrane androgen receptor ZIP9 in mouse Sertoli cells.

Andrology

Kamińska A,Pardyak L,Marek S,Wróbel K,Kotula-Balak M,Bilińska B,Hejmej A

Sun Mar 01 00:00:00 UTC 2020

Human blood vessel organoids as a model of diabetic vasculopathy.

Nature

Wimmer RA,Leopoldi A,Aichinger M,Wick N,Hantusch B,Novatchkova M,Taubenschmid J,Hämmerle M,Esk C,Bagley JA,Lindenhofer D,Chen G,Boehm M,Agu CA,Yang F,Fu B,Zuber J,Knoblich JA,Kerjaschki D,Penninger JM

PA5-40553 was used in Immunocytochemistry-immunoflourescence to suggest that blood vessel organoids derived from human stem cells faithfully recapitulate the structure and function of human blood vessels and are a suitable model for diabetic vasculopathy.

Tue Jan 01 00:00:00 UTC 2019

生物信息学

蛋白别名: basic helix-loop-helix protein OAF1; bHLHb31; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HRT-1; MGC1274

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基因别名: BHLHB31; CHF2; HERP2; HESR1; HEY1; hHRT1; HRT-1; HRT1; OAF1

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UniProt ID: (Human) Q9Y5J3

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Entrez Gene ID: (Human) 23462

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功能

transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding microsatellite binding protein dimerization activity basic helix-loop-helix transcription factor

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