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NeoBiotechnologies
HLA-DP (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-DPB1/2862R)
产品信息
3115-RBM4-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HLA-DPB1/2862R
抗原
Non-T, non-B human acute lymphoblastic leukemia REH6 cell line
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, all are highly polymorphic. HLA-DP molecules have not been studied extensively. HLA-DP is a protein complex found on the surface of antigen-presenting cells, such as dendritic cells, macrophages, and B cells. Its main function is to present peptides derived from extracellular proteins to CD4+ T cells for immune recognition.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta1 domain MHC class II HLA DPB; class II HLA beta chain; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA DP14-beta chain; HLA-DP histocompatibility type, beta-1 subunit; major histocompatibility complex class II antigen beta chain; MHC class II antigen beta chain; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II HLA-DP-beta-1; MHC class II HLA-DRB1; MHC HLA DPB1
基因别名: DPB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1
UniProt ID: (Human) Q30015
Entrez Gene ID: (Human) 3115
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
T cell receptor signaling pathway
positive regulation of T cell activation
interferon-gamma-mediated signaling pathway
