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HMGA1 Antibody (PA5-88708) in WB
Western blot analysis of HMGA1 in rat kidney. Samples were incubated with HMGA1 Polyclonal antibody (Product # PA5-88708) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-88708
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HMGA1 (NP_6659081)
偶联物
形式
Liquid
浓度
0.97 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805083
产品详细信息
Immunogen sequence: MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ; Positive Samples: kidney; Cellular Location: Chromosome, Nucleus
靶标信息
HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:5010; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; high mobility group protein I; HMG-I(Y); MGC12816; MGC4242; MGC4854; OTTHUMP00000016222; OTTHUMP00000016223; OTTHUMP00000016224; OTTHUMP00000039618
基因别名: AL023995; Hmga1; Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy
UniProt ID: (Mouse) P17095, (Rat) Q8K585
Entrez Gene ID: (Mouse) 15361, (Rat) 117062
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA-(apurinic or apyrimidinic site) lyase activity
transcription factor binding
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
retinoid X receptor binding
5'-deoxyribose-5-phosphate lyase activity
DNA binding
transcription factor activity, sequence-specific DNA binding
endodeoxyribonuclease
DNA metabolic process
base-excision repair
transcription from RNA polymerase II promoter
spermatogenesis
positive regulation of transcription from RNA polymerase II promoter
nucleic acid phosphodiester bond hydrolysis
regulation of nucleic acid-templated transcription
DNA catabolic process, endonucleolytic
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of cell proliferation
response to virus
senescence-associated heterochromatin focus assembly
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
oncogene-induced cell senescence
positive regulation of cellular senescence
