Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 6
IKK gamma Antibody (MA5-15155) in ICC/IF
Immunofluorescence analysis of IKK gamma was performed using HEK-293 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with IKK gamma Mouse Monoclonal Antibody (Product # MA5-15155) at 1:100 dilution in 0.1% BSA and incubated overnight at 4 degree and then l... View More
产品信息
MA5-15155
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
H.256.9
抗原
Full length human GST-IKK gamma protein.
偶联物
形式
Liquid
浓度
2.7 mg/mL
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_10977400
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FIP-3; gikk; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKK-gamma; IKK3; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappaB kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mF; NEMO; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188
基因别名: AMCBX1; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
UniProt ID: (Human) Q9Y6K9, (Rat) Q6TMG5
Entrez Gene ID: (Human) 8517, (Rat) 309295
signal transducer activity
protein binding
protein domain specific binding
ubiquitin protein ligase binding
protein homodimerization activity
peroxisome proliferator activated receptor binding
metal ion binding
protein heterodimerization activity
K63-linked polyubiquitin binding
linear polyubiquitin binding
activation of MAPK activity
stimulatory C-type lectin receptor signaling pathway
transcription, DNA-templated
apoptotic process
inflammatory response
immune response
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
JNK cascade
response to virus
regulation of tumor necrosis factor-mediated signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Fc-epsilon receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
establishment of vesicle localization
nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of neuron death
B cell homeostasis
activation of NF-kappaB-inducing kinase activity
NF-kappaB import into nucleus
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
