Invitrogen

IL2RG Polyclonal Antibody

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IL2RG Antibody (PA5-47944) in Neu

Neutralization of IL2RG in CTLL‚2 mouse cytotoxic T cell line. Samples were incubated in IL2RG polyclonal antibody (Product # PA5-47944). Recombinant Human IL‚15 stimulates proliferation in the CTLL‚2 mouse cytotoxic T cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL‚15 (0.8 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse Common γ Chain/IL‚2 Rγ Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 6‚24 µg/mL.

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产品信息

PA5-47944

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1 µg/mL

中和实验 (Neu)

6-24 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Sf 21-derived recombinant mouse Common gamma Chain/IL-2 R gamma Ser25-Ala263

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2608937

产品详细信息

In Western blots, approximately 5% cross-reactivity with recombinant human (rh) IL-2 R gamma is observed and less than 1% cross-reactivity with rhIL-2 R alpha, recombinant mouse IL-2 R beta, and rhIL-15 R is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

靶标信息

IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.

仅用于科研。不用于诊断过程。未经明确授权不得转售。