Invitrogen

IQGAP1 Polyclonal Antibody

查看其他16个IQGAP1抗体

抗体检测数据 (4)
高级验证 (1)

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IQGAP1 Antibody (PA5-82494) in IHC (P)

Immunohistochemical analysis of IQGAP1 in human lymph node using IQGAP1 Polyclonal Antibody (Product # PA5-82494) shows strong membranous positivity in non-germinal center cells.

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IQGAP1 Antibody

Product Image Gallery

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of IQGAP1 in human lymph node using IQGAP1 Polyclonal Antibody (Product # PA5-82494) shows strong membranous positivity in non-germinal center cells.

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of IQGAP1 in human pancreas using IQGAP1 Polyclonal Antibody (Product # PA5-82494) shows strong membranous positivity in exocrine glandular cells.

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of IQGAP1 in human skeletal muscle using IQGAP1 Polyclonal Antibody (Product # PA5-82494) shows no membranous positivity in myocytes as expected.

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of IQGAP1 in human placenta using IQGAP1 Polyclonal Antibody (Product # PA5-82494) shows strong membranous positivity in trophoblastic cells.

IQGAP1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of IQGAP1 demonstrates antibody specificity. Immunohistochemical analysis of IQGAP1 using anti-IQGAP1 Polyclonal Antibody (Product #PA5-82494), shows significant staining of IQGAP1 in endometrium and shows minimal or weak staining in skeletal muscle tissues. The relative expression levels of IQGAP1 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-82494

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

-

免疫组化（石蜡） (IHC (P))

1:200-1:500

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human IQGAP1. Recombinant protein control fragment (Product #RP-90796).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2789652

产品详细信息

Immunogen sequence: NRALESGDVN TVWKQLSSSV TGLTNIEEEN CQRYLDELMK LKAQAHAENN EFITWNDIQA CVDHVNLVVQ EEHERILAIG LINEALDEGD AQKTLQALQI PAAKLEGVLA EVAQHYQDTL IRAKREKAQE IQDESAVLWL DEIQGG

靶标信息

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cdc42-Rac1 effector protein; DISP2; DISPB; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs

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基因别名: AA682088; D7Ertd237e; D7Ertd257e; HUMORFA01; IQGAP1; KIAA0051; mKIAA0051; p195; SAR1

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UniProt ID: (Human) P46940, (Mouse) Q9JKF1

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Entrez Gene ID: (Human) 8826, (Mouse) 29875, (Rat) 361598

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GTPase inhibitor activity GTPase activator activity calcium ion binding protein binding calmodulin binding phosphatidylinositol-3,4,5-trisphosphate binding protein kinase binding protein phosphatase binding protein domain specific binding protein complex binding protein serine/threonine kinase activator activity S100 protein binding Rac GTPase binding cadherin binding involved in cell-cell adhesion Rho GTPase binding G-protein modulator protein-binding activity modulator GTPase-activating protein

regulation of cytokine production signal transduction epidermal growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway negative regulation of GTPase activity negative regulation of dephosphorylation cellular response to platelet-derived growth factor stimulus positive regulation of GTPase activity positive regulation of protein kinase activity platelet-derived growth factor receptor signaling pathway cellular response to calcium ion cellular response to epidermal growth factor stimulus positive regulation of protein serine/threonine kinase activity glomerular visceral epithelial cell development cell-cell adhesion neuron projection extension small GTPase mediated signal transduction regulation of GTPase activity cellular response to fibroblast growth factor stimulus