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产品信息
PA5-38019
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
19 amino acid peptide near the amino terminus of human IQSEC1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2554623
产品详细信息
A recommended positive control is A-20 cell lysate.
At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is not expected to cross-react with IQSEC2.
靶标信息
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; BRAG2; brefeldin A-resistant ARF-GEF2; Brefeldin-resistant Arf-GEF 2 protein; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1
基因别名: ARF-GEP100; ARFGEP100; AW561907; BC026481; BRAG2; cI-43; D6Ertd349e; GEP100; IQSEC1; KIAA0763
UniProt ID: (Human) Q6DN90, (Mouse) Q8R0S2
Entrez Gene ID: (Human) 9922, (Mouse) 232227, (Rat) 686590
