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产品信息
PA5-89979
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 878-1037 of human IPO8 (NP_0063812)
偶联物
形式
Liquid
浓度
3.32 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805874
产品详细信息
Immunogen sequence: TRQLVNREDR SKAEKADMEE NEEISSDEEE TNVTAQAMQS NNGRGEDEEE EDDDWDEEVL EETALEGFST PLDLDNSVDE YQFFTQALIT VQSRDAAWYQ LLMAPLSEDQ RTALQEVYTL AEHRRTVAEA KKKIEQQGGF TFENKGVLSA FNFGTVPSNN; Positive Samples: HeLa, Jurkat, Mouse brain, Rat testis; Cellular Location: Cytoplasm, Nucleus
靶标信息
Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette, sub-family C (CFTR/MRP), member 10; FLJ26580; Imp8; Importin-8; oocyte maturation 1; RAN binding protein 8; Ran-binding protein 8; RanBP8
基因别名: 6230418K12Rik; Abcc10; C130009K11Rik; IPO8; MRP7; OM-1; Om1; RANBP8
UniProt ID: (Human) O15397, (Mouse) Q7TMY7
Entrez Gene ID: (Human) 10526, (Mouse) 320727
