Invitrogen

Jagged1 Polyclonal Antibody

Jagged1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Jagged1 Antibody (PA5-72843) in IHC (P)

Immunohistochemistry of JAG1 in human spleen tissue with Jagged1 Polyclonal Antibody (Product # PA5-72843) at 5 µg/mL.

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产品信息

PA5-72843

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

5 µg/mL

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酶联免疫吸附实验 (ELISA)

Assay-Dependent

染色质免疫沉淀实验 (ChIP)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

JAG1 antibody for a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is within the last 50 amino acids of JAG1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2718697

靶标信息

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Jagged 1 Regulates The Proliferation and Metastasis of Human MDA-T68 Thyroid Cancer Cells.

Cell journal

Chen J,Wang X,Zhang X,Yin J,Zheng Y

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Immunohistochemistry (Paraffin)

Wed Jun 28 00:00:00 UTC 2023

Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells.

International journal of molecular sciences

Ham SW,Kim JY,Seo S,Hong N,Park MJ,Kim Y,Jang J,Park S,Lee SJ,Kim JK,Kim EJ,Kim SO,Kim SC,Park JW,Kim H

PA5-72843 was used in ChIP assay to show that ANXA2 maintains the function of the NOTCH receptor-independent JICD1 signaling pathway by stabilizing JICD1, and the targeted suppression of JICD1-driven CSC properties can be achieved by blocking its interaction with ANXA2.

Sat Sep 30 00:00:00 UTC 2023

C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation.

Human molecular genetics

van Ingen E,van den Homberg DAL,van der Bent ML,Mei H,Papac-Milicevic N,Kremer V,Boon RA,Quax PHA,Wojta J,Nossent AY

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Western Blot

Thu Mar 31 00:00:00 UTC 2022

Nuclear and Membrane Receptors for Sex Steroids Are Involved in the Regulation of Delta/Serrate/LAG-2 Proteins in Rodent Sertoli Cells.

International journal of molecular sciences

Lustofin S,Kamińska A,Brzoskwinia M,Cyran J,Kotula-Balak M,Bilińska B,Hejmej A

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Western Blot

Fri Feb 18 00:00:00 UTC 2022

A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy.

Cell death & disease

Gong M,Yan F,Yu L,Li F

PA5-72843 was used in Western Blotting to study a dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy.

Sat Aug 27 00:00:00 UTC 2022

Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling pathway.

Synapse (New York, N.Y.)

Cheng F,Qin W,Yang AX,Yan FF,Chen Y,Ma JX

PA5-72843 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate that propofol inhibits inflammatory responses and the Notch signaling pathway via miR-140-3p/JAG1 to alleviate NP.

Fri Oct 01 00:00:00 UTC 2021

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

PA5-72843 was used in Immunohistochemistry to examine whether activation of Notch receptors and expression of Notch ligands and effector genes in rat seminiferous epithelium are controlled by androgen signaling during puberty.