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Antibody is stable for 24 months.
Positive Control: HeLa cells. Cellular Localization: Nucleus.
Specificity Comments: Kr ppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and which co-regulators they interact with. KLF17 (Kr ppel-like factor 17), whose alternative names include ZNF393 (zinc finger protein 393) or zfp393, is a 389 amino acid nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family. Expressed in testis and ovary, KLF17 may function as a germ cell-specific transcription factor involved in oocyte development and spermatid differentiation. Containing three C2H2-type zinc fingers which bind G/C-rich sites, KLF17 activates transcription from CACCC-box elements.
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ40160; Krueppel-like factor 17; Kruppel-like factor 17; novel zinc-finger protein; Zinc finger protein 393; ZLF393
基因别名: KLF17; Zfp393; ZNF393
UniProt ID: (Human) Q5JT82
Entrez Gene ID: (Human) 128209