Invitrogen

KLRB1 Polyclonal Antibody

产品信息

PA5-51096

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1:20,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from the Internal region of human CD161 (aa 101-150).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2636544

产品详细信息

KLRB1 / CD161 Polyclonal Antibody detects endogenous levels of KLRB1 / CD161 protein.

靶标信息

KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Antigen 3.2.3; C-type lectin domain family 5 member B; CD161; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; HNKR-P1a; Immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1 complex; Killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; Killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; Killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; Killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; klrb1b {ECO:0000312|EMBL:AAQ11375.1}; klrb1b {ECO:0000312|RGD:2975}; lectin-like transmembrane protein Nkrp1g; Ly-55A; ly-55b; Ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; Lymphocyte antigen 55A; lymphocyte antigen 55b; Lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; Natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; Natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; Natural killer cell surface protein P1-3.2.3; Natural killer cell surface protein P1A; Natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1.7; NKR-P1A; NKR-P1D

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基因别名: 4930431A04Rik; CD161; CLEC5B; Gm4696; hNKR-P1A; KLRB1; Klrb1a; Klrb1b; Klrb1d; Klrb1f; Klrb1g; Klrb6; Ly-55; ly-55A; Ly55; Ly55a; Ly55b; Ly55d; NKR; NKR-P1; NKR-P1.7; NKR-P1A; NKR-P1B; NKR-P1D; Nkr-p1e; NKR-P1G; Nkrp-1e; Nkrp1-a; Nkrp1-b; NKRP12; NKRP1A; Nkrp1b; Nkrp1d; Nkrp1e; Nkrp1g