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产品信息
MA1-12555
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
1C10
抗原
Lymphokine-activated killer Cells.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
0.08% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2132868
靶标信息
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
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生物信息学
蛋白别名: CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; immunoreceptor NKR-P1G; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1 complex; Killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; Killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1D; Killer cell lectin-like receptor subfamily B member 1G; lectin-like transmembrane protein Nkrp1g; Ly-55A; ly-55b; Ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; Lymphocyte antigen 55A; lymphocyte antigen 55b; Lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; Natural killer cell surface protein NKR-P1B allele B6; natural killer cell surface protein NKR-P1B allele SJL/BALB; Natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; Natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR-P1 2; NKR-P1 34; NKR-P1.7; NKR-P1A; NKR-P1D
基因别名: 4930431A04Rik; Gm4696; Klrb1; Klrb1a; Klrb1b; Klrb1d; Klrb1g; Klrb6; Ly-55; ly-55A; Ly55; Ly55a; Ly55b; Ly55d; NKR-P1.7; NKR-P1A; NKR-P1B; NKR-P1D; NKR-P1G; Nkrp-1e; Nkrp1-a; Nkrp1-b; NKRP12; Nkrp1a; Nkrp1b; Nkrp1d; Nkrp1g
UniProt ID: (Mouse) Q0ZUP1, (Mouse) P27811, (Mouse) Q99JB4
Entrez Gene ID: (Mouse) 100043861, (Mouse) 17057, (Mouse) 80782
