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产品信息
PA5-87990
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 26-288 of human Legumain (LGMN) (NP_0055973?)
偶联物
形式
Liquid
浓度
2.01 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804568
产品详细信息
Positive Samples: Mouse lung, Mouse liver; Cellular Location: Lysosome
Immunogen sequence: GGKHWVVIVA GSNGWYNYRH QADACHAYQI IHRNGIPDEQ IVVMMYDDIA YSEDNPTPGI VINRPNGTDV YQGVPKDYTG EDVTPQNFLA VLRGDAEAVK GIGSGKVLKS GPQDHVFIYF TDHGSTGILV FPNEDLHVKD LNETIHYMYK HKMYRKMVFY IEACESGSMM NHLPDNINVY ATTAANPRES SYACYYDEKR STYLGDWYSV NWMEDSDVED LTKETLHKQY HLVKSHTNTS HVMQYGNKTI STMKVMQFQG MKR
靶标信息
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AEP; Asparaginyl endopeptidase; cysteine protease 1; Legumain; preprolegumain; Protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1EC 3.4.22.34
基因别名: AEP; AI746452; AU022324; LGMN; LGMN1; PRSC1
UniProt ID: (Human) Q99538, (Mouse) O89017, (Rat) Q9R0J8
Entrez Gene ID: (Human) 5641, (Mouse) 19141, (Rat) 63865
toll-like receptor signaling pathway
renal system process
proteolysis
vacuolar protein processing
response to acidic pH
antigen processing and presentation of exogenous peptide antigen via MHC class II
receptor catabolic process
negative regulation of multicellular organism growth
vitamin D metabolic process
negative regulation of neuron apoptotic process
proteolysis involved in cellular protein catabolic process
negative regulation of ERBB signaling pathway
