Invitrogen

LHX2 Polyclonal Antibody

LHX2 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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LHX2 Antibody (PA5-78287) in IHC (F)

LHX2 Polyclonal Antibody detects LHX2 protein expression by immunohistochemical analysis. Sample: Frozen sectioned adult mouse retina. Green: LHX2 protein stained by LHX2 Polyclonal Antibody (Product # PA5-78287) diluted at 1:250. Red: beta Tubulin 3/ TUJ1, stained by beta Tubulin 3/ TUJ1 antibody [GT11710] diluted at 1:250. Blue: Fluoroshield with DAPI .

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产品信息

PA5-78287

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:20,000

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

1:100-1:1,000

凝胶阻滞分析 (GS)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the C-terminus region of human LHX2. The exact sequence is proprietary.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.97 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2736088

产品详细信息

Positive Control: 293T, A431, HeLa, HepG2, Neuro 2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, mouse brain, mouse eye

Predicted Reactivity: Pig (98%), Chicken (81%), Rhesus Monkey (98%), Bovine (98%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.

Science advances

Chen GD,Fatima I,Xu Q,Rozhkova E,Fessing MY,Mardaryev AN,Sharov AA,Xu GL,Botchkarev VA

PA5-78287 was used in Immunohistochemistry to demonstrate the essential roles for Tet2/3 in establishment of lineage-specific gene expression program and control of Dlx3/Krt25/Krt28 axis in hair follicle epithelial cells and implicate modulation of DNA methylation as a novel approach for hair growth control.

Fri Jan 13 00:00:00 UTC 2023

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.

Proceedings of the National Academy of Sciences of the United States of America

Williams BL,Seager NA,Gardiner JD,Pappas CM,Cronin MC,Amat di San Filippo C,Anstadt RA,Liu J,Toso MA,Nichols L,Parnell TJ,Eve JR,Heinz S,Hayes MGB,Bartel PL,Zouache MA,Richards BT,Hageman GS

PA5-78287 was used in Gel Shift, Immunohistochemistry (Frozen), Western Blot to show that HTRA1 messenger RNA (mRNA) is reduced in retinal pigment epithelium (RPE) but not in neural retina or choroid tissues derived from human donors with homozygous risk at the 10q26 locus.

Tue Jul 27 00:00:00 UTC 2021

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.

Proceedings of the National Academy of Sciences of the United States of America

Williams BL,Seager NA,Gardiner JD,Pappas CM,Cronin MC,Amat di San Filippo C,Anstadt RA,Liu J,Toso MA,Nichols L,Parnell TJ,Eve JR,Heinz S,Hayes MGB,Bartel PL,Zouache MA,Richards BT,Hageman GS