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产品信息
PA5-34470
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid peptide near the carboxy terminus of human LMX1A
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551822
产品详细信息
A suggested positive control is rat brain tissue lysate.
PA5-34470 can be used with blocking peptide PEP-1512.
靶标信息
The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: LIM homeobox transcription factor 1, alpha; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1; LMX-1.1; MGC87616; shaker short-tail
基因别名: dr; dreher; LMX1; LMX1.1; LMX1A; sst
UniProt ID: (Human) Q8TE12, (Mouse) Q9JKU8
Entrez Gene ID: (Human) 4009, (Rat) 289201, (Mouse) 110648
regulation of cell growth
transcription, DNA-templated
axon guidance
dentate gyrus development
cerebellum development
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
regulation of transcription, DNA-templated
central nervous system development
brain development
regulation of gene expression
hippocampus development
central nervous system neuron differentiation
neuron differentiation
midbrain development
multicellular organism development
