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LMX1A Antibody (710980) in WB
Western blot analysis was performed on tissue extracts (30 µg lysate) of Rat Brain (Lane 1), Mouse Brain (Lane 2), Mouse Cerebellum (Lane 3) and Mouse heart (Lane 4). The blots were probed with Anti-Lmx1a Recombinant Rabbit Superclonal™ Antibody (Product # 710980, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 42 kDa band corresponding to Lmx1a was observed according to the tested tissues. Known quantity o... View More
产品信息
710980
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
20HCLC
抗原
Protein corresponding to Human LMX1A (aa 195-370)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2577142
产品详细信息
This antibody is predicted to react with Monkey, Cat and Rabbit.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LIM homeobox transcription factor 1, alpha; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1; LMX-1.1; MGC87616; shaker short-tail
基因别名: dr; dreher; LMX1; LMX1.1; LMX1A; sst
UniProt ID: (Human) Q8TE12, (Mouse) Q9JKU8
Entrez Gene ID: (Human) 4009, (Rat) 289201, (Mouse) 110648
regulation of cell growth
transcription, DNA-templated
axon guidance
dentate gyrus development
cerebellum development
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
regulation of transcription, DNA-templated
central nervous system development
brain development
regulation of gene expression
hippocampus development
central nervous system neuron differentiation
neuron differentiation
midbrain development
multicellular organism development
