Invitrogen

LNP Polyclonal Antibody

LNP Antibody in Immunocytochemistry (ICC/IF)

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LNP Antibody (PA5-53133) in ICC/IF

Immunofluorescent staining of LNP in human cell line U-251 MG using a LNP Polyclonal Antibody (Product # PA5-53133) shows localization to nucleoplasm and endoplasmic reticulum.

LNP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

LNP Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. U-138 mg were transfected with, control siRNA, LNP siRNA (probe #1), and LNP siRNA (probe #2) and a decrease in signal intensity was observed in Western Blot application using anti-LNP Polyclonal Antibody (Product # PA5-53133) used at a dilution of 0.4 µg/mL. Anti-GAPDH was used as a loading control. {KD}

产品信息

PA5-53133

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

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免疫组化（石蜡） (IHC (P))

1:200-1:500

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human LNP. Recombinant protein control fragment (Product #RP-90981).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.20 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2643417

产品详细信息

Immunogen sequence: GALDRIVEYL VGDGPQNRYA LICQQCFSHN GMALKEEFEY IAFRCAYCFF LNPARKTRPQ APRLPEFSFE KRQVVEGSSS VGPLPSGSVL SSDNQFNEES LEHDVLDDNT EQTDDKIPAT EQ

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 71%.

靶标信息

LNP (LNPK) is an endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. It is involved in the stabilization of nascent three-way ER tubular junctions within the ER network and may play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. LNP is involved in central nervous system development and may be involved in limb development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Unscrambling exit site patterns on the endoplasmic reticulum as a quenched demixing process.

Biophysical journal

Speckner K,Stadler L,Weiss M

PA5-53133 was used in Western Blotting to investigate the spatial distribution of ER exit sites (ERESs) in mammalian cells and their relationship to the underlying endoplasmic reticulum (ER) morphology.

Tue Jun 15 00:00:00 UTC 2021

生物信息学

蛋白别名: 2310011O18Rik; 4921514L11Rik; Endoplasmic reticulum junction formation protein lunapark; ER junction formation factor lunapark; limb and neural patterns; Lunapark

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基因别名: KIAA1715; LNP; LNP1; LNPK; Ul; ulnaless

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UniProt ID: (Human) Q9C0E8

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Entrez Gene ID: (Human) 80856

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功能

metal ion binding

参与通路

blood coagulation regulation of chondrocyte differentiation embryonic forelimb morphogenesis embryonic digit morphogenesis limb development endoplasmic reticulum tubular network organization