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LNPEP Antibody (PA5-88277) in IHC (P)
Immunohistochemistry analysis of LNPEP in paraffin-embedded human placenta. Samples were incubated with LNPEP Polyclonal antibody (Product # PA5-88277) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-88277
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_0055662)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804794
产品详细信息
Immunogen sequence: MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART; Positive Samples: 293T, HT-29, U-87MG, HeLa, Jurkat, Mouse heart, Rat heart; Cellular Location: Cell membrane, Single-pass type II membrane protein
靶标信息
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aminopeptidase Vp165; angiotensin IV receptor; AT (4) receptor; Cystinyl aminopeptidase; GP160; insulin-regulated aminopeptidase; Insulin-regulated membrane aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; Insulin-responsive aminopeptidase; IRAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; vasopressinase; Vesicle protein of 165 kDa; vp160; Vp165
基因别名: 2010309L07Rik; 4732490P18Rik; CAP; gp160; IRAP; LNPEP; OTASE; P-LAP; PLAP; Vp165
UniProt ID: (Human) Q9UIQ6, (Rat) P97629, (Mouse) Q8C129
Entrez Gene ID: (Human) 4012, (Rat) 171105, (Mouse) 240028
protein polyubiquitination
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
proteolysis
signal transduction
cell-cell signaling
female pregnancy
regulation of blood pressure
protein catabolic process
peptide catabolic process
SMAD protein signal transduction
membrane organization
response to hormone
neuropeptide catabolic process
angiotensin-activated signaling pathway
positive regulation of blood pressure
regulation of long-term neuronal synaptic plasticity
