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MACC1 Antibody (PA5-115530) in IHC (P)
Immunohistochemistry analysis of MACC1 in human normal tissues adjacent to esophageal cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115530) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115530
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MACC1(Accession Q6ZN28), corresponding to amino acid residues N86-R136.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900166
产品详细信息
Antibody detects endogenous levels of total MACC1.
靶标信息
MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5
基因别名: 4732474O15Rik; 7A5; Gm267; MACC1; RGD1309838; SH3BP4L
UniProt ID: (Human) Q6ZN28
Entrez Gene ID: (Human) 346389, (Rat) 314539, (Mouse) 238455
