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MYSM1 Antibody (PA5-91929) in WB
Western blot analysis of MYSM1 in extracts of various cell lines. Samples were incubated with MYSM1 Polyclonal antibody (Product # PA5-91929) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-91929
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 720-821 of human MYSM1 (NP_0010789561)
偶联物
形式
Liquid
浓度
0.47 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806331
产品详细信息
Positive Samples: U-87MG, A-431, HepG2, HeLa, Jurkat, Mouse brain, Rat brain; Cellular Location: Nucleus
Immunogen sequence: SYRLPYKFEV QQMLEEPQWG LVFEKTRWII EKYRLSHSSV PMDKIFRRDS DLTCLQKLLE CMRKTLSKVT NCFMAEEFLT EIENLFLSNY KSNQENGVTE EN
靶标信息
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2A-DUB; Deubiquitinase MYSM1; histone H2A deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1; Myb-like, SWIRM and MPN domains 1; RP4-592A1.1
基因别名: 2A-DUB; 2ADUB; C130067A03Rik; C530050H10Rik; KIAA1915; MYSM1; RGD1311787
UniProt ID: (Human) Q68DD3, (Mouse) Q69Z66
Entrez Gene ID: (Human) 114803, (Rat) 298247, (Mouse) 320713
DNA binding
transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
metallopeptidase activity
protein complex binding
histone binding
metal ion binding
molecular_function
chromatin binding
peptidase activity
hydrolase activity
pyroglutamyl-peptidase activity
chromatin/chromatin-binding, or -regulatory protein
chromatin remodeling
transcription, DNA-templated
regulation of cell migration
monoubiquitinated histone H2A deubiquitination
positive regulation of transcription from RNA polymerase II promoter
regulation of hair follicle development
proteolysis
biological_process
regulation of transcription, DNA-templated
chromatin modification
