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产品信息
PA5-54070
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644393
产品详细信息
Immunogen sequence: NGDLDEVKDY VAKGEDVNRT LEGGRKPLHY AADCGQLEIL EFLLLKGADI NAPDKHHITP LLSAVYEGHV SCVKLLLSKG ADKTVKGPDG LTAFEATDNQ AIKALLQ
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
靶标信息
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6. 4 kDa tumor antigen that is associated with myeloproliferative disease.
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生物信息学
蛋白别名: Granule cell differentiation protein; growth factor; Myotrophin; Protein V-1; stimulates myocyte growth; V-1 protein
基因别名: 5033418D15Rik; GCDP; MTPN; V-1; V1
UniProt ID: (Human) P58546, (Rat) P62775, (Mouse) P62774
Entrez Gene ID: (Human) 136319, (Rat) 79215, (Mouse) 14489
catecholamine metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cardiac muscle hypertrophy
cell growth
cerebellar granule cell differentiation
neuron differentiation
positive regulation of cell growth
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
positive regulation of protein metabolic process
regulation of barbed-end actin filament capping
regulation of translation
regulation of striated muscle tissue development
cellular response to mechanical stimulus
