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产品信息
PA5-34508
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the center of human NELF
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551860
产品详细信息
A suggested positive control is Hela cell lysate.
PA5-34508 can be used with blocking peptide PEP-1551.
靶标信息
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
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生物信息学
蛋白别名: Jacob protein; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NMDA receptor synaptonuclear signaling and neuronal migration factor
基因别名: HH9; Jac; Jacob; NELF; NSMF
UniProt ID: (Human) Q6X4W1, (Rat) Q9EPI6, (Mouse) Q99NF2
Entrez Gene ID: (Human) 26012, (Rat) 117536, (Mouse) 56876
positive regulation of protein dephosphorylation
regulation of neuron apoptotic process
regulation of neuronal synaptic plasticity
regulation of dendrite morphogenesis
cellular response to amino acid stimulus
cellular response to electrical stimulus
cellular response to gonadotropin stimulus
positive regulation of neuron migration
biological_process
