Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
NeoBiotechnologies
NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) Monoclonal Antibody (NKX61/2561)
产品信息
4825-MSM1-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2c, kappa
分类
Monoclonal
类型
Antibody
克隆号
NKX61/2561
抗原
Recombinant full-length human NKX6.1 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain. Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; NK homeo box, family 6, member A; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1
基因别名: NKX6-1; NKX6.1; NKX6A
UniProt ID: (Human) P78426
Entrez Gene ID: (Human) 4825
negative regulation of transcription from RNA polymerase II promoter
neuron migration
transcription from RNA polymerase II promoter
smoothened signaling pathway
organ morphogenesis
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of axon extension
pancreas development
positive regulation of insulin secretion
response to nicotine
response to drug
type B pancreatic cell proliferation
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of glial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
detection of glucose
cellular response to cytokine stimulus
cellular response to peptide hormone stimulus
type B pancreatic cell maturation
positive regulation of type B pancreatic cell development
regulation of neuron migration
