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产品信息
OSN00076W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 300-400 of mouse NMDAR2D conjugated to an immunogenic carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: NMDAR2D.
靶标信息
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EB11; estrogen receptor binding CpG island; GluN2D; glur epsilon 4; GluRepsilon4; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor; Glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; ionotropic NMDA glutamate receptor epsilon 4 subunit type 2; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D
基因别名: EB11; GluN2D; GRIN2D; NMDAR2D; NR2D
UniProt ID: (Human) O15399, (Mouse) Q03391
Entrez Gene ID: (Human) 2906, (Mouse) 14814
NMDA glutamate receptor activity
Ras guanyl-nucleotide exchange factor activity
extracellular-glutamate-gated ion channel activity
protein binding
receptor activity
ionotropic glutamate receptor activity
ion channel activity
cation channel activity
glutamate binding
voltage-gated cation channel activity
neurotransmitter binding
transmembrane signal receptor
MAPK cascade
startle response
signal transduction
chemical synaptic transmission
adult locomotory behavior
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
positive regulation of GTPase activity
regulation of sensory perception of pain
transport
ion transport
cation transport
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
detection of mechanical stimulus involved in sensory perception of pain
excitatory postsynaptic potential
cation transmembrane transport
