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NMDAR2D Antibody (PA5-87624) in WB
Western blot analysis of NMDAR2D in extracts of various cell lines. Samples were incubated with NMDAR2D Polyclonal antibody (Product # PA5-87624) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-87624
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 330-480 of human GRIN2D (NP_0008272)
偶联物
形式
Liquid
浓度
3.07 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804299
产品详细信息
Immunogen sequence: GAQALLRDYG FLPELGHDCR AQNRTHRGES LHRYFMNITW DNRDYSFNED GFLVNPSLVV ISLTRDRTWE VVGSWEQQTL RLKYPLWSRY GRFLQPVDDT QHLTVATLEE RPFVIVEPAD PISGTCIRDS VPCRSQLNRT HSPPPDAPRP E; Positive Samples: SH-SY5Y, Mouse liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
靶标信息
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EB11; estrogen receptor binding CpG island; GluN2D; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor; Glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D
基因别名: EB11; GluN2D; GRIN2D; NMDAR2D; NR2D
UniProt ID: (Human) O15399
Entrez Gene ID: (Human) 2906
