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产品信息
PA5-92994
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human NRBF2 (NP_1103862)
偶联物
形式
Liquid
浓度
2.03 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806576
产品详细信息
Immunogen sequence: MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN
Positive Samples: SKOV3, HepG2, 293T, HeLa, Jurkat, Mouse brain, Mouse heart, Rat brain; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Nucleus, autophagosome
靶标信息
NRBF2 (nuclear receptor-binding factor 2) modulates transcriptional activation by target nuclear receptors. It is involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). NRBF2 stabilizes the PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Comodulator of PPAR and RXR; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; NRBF-2; nuclear receptor binding factor-2; Nuclear receptor-binding factor 2
基因别名: COPR; COPR1; COPR2; NRBF-2; NRBF2
UniProt ID: (Human) Q96F24, (Rat) Q9QYK3, (Mouse) Q8VCQ3
Entrez Gene ID: (Human) 29982, (Rat) 58839, (Mouse) 641340
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
autophagy
regulation of autophagy
response to endoplasmic reticulum stress
regulation of lipid kinase activity
transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
regulation of transcription from RNA polymerase II promoter
