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Noggin Antibody (PA5-96996) in WB
Western blot analysis of Noggin in extracts of various cell lines. Samples were incubated with Noggin Polyclonal antibody (Product # PA5-96996) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-96996
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 28-232 of human NOG (NP_0054411)
偶联物
形式
Liquid
浓度
1.61 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808798
产品详细信息
Immunogen sequence: QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC; Positive Samples: Mouse brain, Mouse spinal cord
靶标信息
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Noggin; Noggin precursor
基因别名: Nog
UniProt ID: (Mouse) P97466
Entrez Gene ID: (Rat) 25495, (Mouse) 18121
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
urogenital system development
ureteric bud development
in utero embryonic development
endoderm formation
mesoderm formation
epithelial to mesenchymal transition
neural plate morphogenesis
neural tube closure
pattern specification process
axon guidance
central nervous system development
brain development
motor neuron axon guidance
dorsal/ventral pattern formation
negative regulation of gene expression
spinal cord development
cell differentiation in hindbrain
neural tube development
pituitary gland development
negative regulation of cell migration
BMP signaling pathway
regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
somatic stem cell population maintenance
wound healing
middle ear morphogenesis
embryonic digit morphogenesis
regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
axial mesoderm development
notochord morphogenesis
anatomical structure formation involved in morphogenesis
embryonic skeletal system development
negative regulation of astrocyte differentiation
mesenchymal cell differentiation
positive regulation of epithelial cell proliferation
cartilage development
negative regulation of cardiac muscle cell proliferation
limb development
embryonic skeletal joint morphogenesis
negative regulation of cytokine activity
face morphogenesis
negative regulation of pathway-restricted SMAD protein phosphorylation
lung morphogenesis
prostatic bud formation
ureteric bud formation
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of cartilage development
somite development
cellular response to BMP stimulus
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of glomerulus development
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of apoptotic signaling pathway
multicellular organism development
cell differentiation
negative regulation of cell differentiation
