Product References
Indomethacin Induces Spermidine/Spermine-N1-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells.
Biomolecules
Buelvas N,Ugarte-Vio I,Asencio-Leal L,Muñoz-Uribe M,Martin-Martin A,Rojas-Fernández A,Jara JA,Tapia JC,Arias ME,López-Muñoz RA
39-6400 was used in Western Blot to investigate the influence of the PPAR-γ on the SSAT-1 expression in two lung cancer cell lines: H1299 and A549.
Tue Sep 12 00:00:00 UTC 2023
Indomethacin Induces Spermidine/Spermine-N1-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells.
Biomolecules
Buelvas N,Ugarte-Vio I,Asencio-Leal L,Muñoz-Uribe M,Martin-Martin A,Rojas-Fernández A,Jara JA,Tapia JC,Arias ME,López-Muñoz RA
39-6400 was used in Western Blot to investigate the influence of the PPAR-γ on the SSAT-1 expression in two lung cancer cell lines: H1299 and A549.
Tue Sep 12 00:00:00 UTC 2023
PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer.
Molecular & cellular proteomics : MCP
Palmieri M,Catimel B,Mouradov D,Sakthianandeswaren A,Kapp E,Ang CS,Williamson NA,Nowell CJ,Christie M,Desai J,Gibbs P,Burgess AW,Sieber OM
39-6400 was used in Immunocytochemistry to indicate PI3Kα translocation mediates nuclear PtdIns(3,4,5)P3 effector signaling in human CRC, modulating signaling responses.
Sat Apr 01 00:00:00 UTC 2023
A novel role for nucleolin in splice site selection.
RNA biology
Shefer K,Boulos A,Gotea V,Arafat M,Ben Chaim Y,Muharram A,Isaac S,Eden A,Sperling J,Elnitski L,Sperling R
39-6400 was used in Western Blotting to present nucleolin as the first protein of a nuclear quality control mechanism regulating splice site selection through its direct and specific binding to initiator-tRNA.
Mon Mar 28 00:00:00 UTC 2022
A novel role for nucleolin in splice site selection.
RNA biology
Shefer K,Boulos A,Gotea V,Arafat M,Ben Chaim Y,Muharram A,Isaac S,Eden A,Sperling J,Elnitski L,Sperling R
39-6400 was used in Western Blotting to present nucleolin as the first protein of a nuclear quality control mechanism regulating splice site selection through its direct and specific binding to initiator-tRNA.
Mon Mar 28 00:00:00 UTC 2022
Nuclear speckle integrity and function require TAO2 kinase.
Proceedings of the National Academy of Sciences of the United States of America
Gao S,Esparza M,Dehghan I,Aksenova V,Zhang K,Batten K,Ferretti MB,Begg BE,Cagatay T,Shay JW,García-Sastre A,Goldsmith EJ,Chen ZJ,Dasso M,Lynch KW,Cobb MH,Fontoura BMA
39-6400 was used in Western Blotting to find that a nuclear pool of TAO2 is localized at nuclear speckles and interacts with nuclear speckle factors involved in RNA splicing and nuclear export, including SRSF1 and Aly/Ref.
Tue Jun 21 00:00:00 UTC 2022
Nuclear speckle integrity and function require TAO2 kinase.
Proceedings of the National Academy of Sciences of the United States of America
Gao S,Esparza M,Dehghan I,Aksenova V,Zhang K,Batten K,Ferretti MB,Begg BE,Cagatay T,Shay JW,García-Sastre A,Goldsmith EJ,Chen ZJ,Dasso M,Lynch KW,Cobb MH,Fontoura BMA
39-6400 was used in Western Blotting to find that a nuclear pool of TAO2 is localized at nuclear speckles and interacts with nuclear speckle factors involved in RNA splicing and nuclear export, including SRSF1 and Aly/Ref.
Tue Jun 21 00:00:00 UTC 2022
Genome-wide survey of D/E repeats in human proteins uncovers their instability and aids in identifying their role in the chromatin regulator ATAD2.
iScience
Shukla S,Lazarchuk P,Pavlova MN,Sidorova JM
39-6400 was used in ELISA, Immunocytochemistry, Western Blot to demonstrate that D/E repeat deletion in ATAD2 suppresses its binding to nascent and mature chromatin and to the constitutive pericentromeric heterochromatin, where ATAD2 represses satellite transcription.
Thu Dec 22 00:00:00 UTC 2022
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells.
Frontiers in molecular biosciences
Lazarchuk P,Nguyen VN,Brunon S,Pavlova MN,Sidorova JM
39-6400 was used in Western Blotting to assess STING subcellular distribution and its ability to activate.
Wed Aug 30 00:00:00 UTC 2023
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
The EMBO journal
Ghosh S,Guimaraes JC,Lanzafame M,Schmidt A,Syed AP,Dimitriades B,Börsch A,Ghosh S,Mittal N,Montavon T,Correia AL,Danner J,Meister G,Terracciano LM,Pfeffer S,Piscuoglio S,Zavolan M
39-6400 was used in Western Blotting to report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis.
Tue Sep 15 00:00:00 UTC 2020
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
The EMBO journal
Ghosh S,Guimaraes JC,Lanzafame M,Schmidt A,Syed AP,Dimitriades B,Börsch A,Ghosh S,Mittal N,Montavon T,Correia AL,Danner J,Meister G,Terracciano LM,Pfeffer S,Piscuoglio S,Zavolan M
39-6400 was used in Western Blotting to report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer cells, where it curbs accumulation of double-stranded RNAs (dsRNAs) and consequent induction of interferon responses and apoptosis.
Tue Sep 15 00:00:00 UTC 2020
Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells.
Molecular and cellular biology
Lazarchuk P,Hernandez-Villanueva J,Pavlova MN,Federation A,MacCoss M,Sidorova JM
39-6400 was used in Western Blotting to discover whether the overexpression of ATAD2 shifts the balance of H4 acetylation by protecting this mark from removal and that HDAC2 but not HDAC1 can effectively compete with ATAD2 for the target acetyls.
Mon Apr 13 00:00:00 UTC 2020
Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.
Scientific reports
Ognibene M,Pezzolo A
39-6400 was used in Western Blot, Immunohistochemistry, Immunocytochemistry to find that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
Fri Jul 31 00:00:00 UTC 2020
Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.
Scientific reports
Ognibene M,Pezzolo A
39-6400 was used in Western Blot, Immunohistochemistry, Immunocytochemistry to find that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
Fri Jul 31 00:00:00 UTC 2020
Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.
Scientific reports
Ognibene M,Pezzolo A
39-6400 was used in Western Blot, Immunohistochemistry, Immunocytochemistry to find that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
Fri Jul 31 00:00:00 UTC 2020
Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.
Scientific reports
Ognibene M,Pezzolo A
39-6400 was used in Western Blot, Immunohistochemistry, Immunocytochemistry to find that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
Fri Jul 31 00:00:00 UTC 2020
Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.
Scientific reports
Ognibene M,Pezzolo A
39-6400 was used in Western Blot, Immunohistochemistry, Immunocytochemistry to find that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
Fri Jul 31 00:00:00 UTC 2020
Loss of PHF6 leads to aberrant development of human neuron-like cells.
Scientific reports
Fliedner A,Gregor A,Ferrazzi F,Ekici AB,Sticht H,Zweier C
Published figure using Nucleolin monoclonal antibody (Product # 39-6400) in Immunocytochemistry
Wed Nov 04 00:00:00 UTC 2020
Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein.
mSphere
Beyleveld G,Chin DJ,Moreno Del Olmo E,Carter J,Najera I,Cillóniz C,Shaw ML
Published figure using Nucleolin monoclonal antibody (Product # 39-6400) in Immunofluorescence
Wed Nov 14 00:00:00 UTC 2018
Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells.
Journal of virology
Hidalgo P,Anzures L,Hernández-Mendoza A,Guerrero A,Wood CD,Valdés M,Dobner T,Gonzalez RA
39-6400 was used in immunocytochemistry and western blot to characterize viral replication compartments isolated from adenovirus-infected cells for biochemical, morphological, and functional properties
Wed Jan 13 00:00:00 UTC 2016
Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest.
The Journal of biological chemistry
Kehrli K,Phelps M,Lazarchuk P,Chen E,Monnat R,Sidorova JM
39-6400 was used in western blot to propose that WRN interacts with HDACs to facilitate activity of stalled replication forks under conditions of replication stress
Fri Nov 18 00:00:00 UTC 2016
Molecular evolution and in vitro characterization of Botryllus histocompatibility factor.
Immunogenetics
Taketa DA,Nydam ML,Langenbacher AD,Rodriguez D,Sanders E,De Tomaso AW
39-6400 was used in immunocytochemistry to study allorecognition using Botryllus schlosseri.
Thu Oct 01 00:00:00 UTC 2015
Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells.
Oncoscience
Kehrli KR,Sidorova JM
Published figure using Nucleolin monoclonal antibody (Product # 39-6400) in Western Blot
Tue Sep 29 00:00:00 UTC 2020
CRISPR/Cas9 allows efficient and complete knock-in of a destabilization domain-tagged essential protein in a human cell line, allowing rapid knockdown of protein function.
PloS one
Park A,Won ST,Pentecost M,Bartkowski W,Lee B
39-6400 was used in Immunofluorescence to assess the feasibility of using CRISPR/Cas9 to achieve complete knock-in to DD-tag Treacher Collins-Franceschetti syndrome 1 in human 293T cells.
Tue Dec 30 00:00:00 UTC 2014
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
Molecular biology of the cell
Lirussi L,Antoniali G,Vascotto C,D'Ambrosio C,Poletto M,Romanello M,Marasco D,Leone M,Quadrifoglio F,Bhakat KK,Scaloni A,Tell G
Mon Oct 01 00:00:00 UTC 2012
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
Molecular biology of the cell
Lirussi L,Antoniali G,Vascotto C,D'Ambrosio C,Poletto M,Romanello M,Marasco D,Leone M,Quadrifoglio F,Bhakat KK,Scaloni A,Tell G
Mon Oct 01 00:00:00 UTC 2012
Nucleophosmin delocalization in thyroid tumour cells.
Endocrine pathology
Pianta A,Puppin C,Passon N,Franzoni A,Romanello M,Tell G,Di Loreto C,Bulotta S,Russo D,Damante G
39-6400 was used in immunocytochemistry to examine the localization of nucleophosmin in thyroid tumors.
Tue Mar 01 00:00:00 UTC 2011
Secretome-based identification and characterization of potential biomarkers in thyroid cancer.
Journal of proteome research
Kashat L,So AK,Masui O,Wang XS,Cao J,Meng X,Macmillan C,Ailles LE,Siu KW,Ralhan R,Walfish PG
Fri Nov 05 00:00:00 UTC 2010
Two novel NPM1 mutations in a therapy-responder AML patient.
Hematological oncology
Pianta A,Fabbro D,Damiani D,Tiribelli M,Fanin R,Franzoni A,Romanello M,Tell G,Di Loreto C,Damante G
39-6400 was used in immunocytochemistry to describe a case of a therapy-responder acute myeloid leukemia patient bearing two novel NPM1 mutations
Wed Sep 01 00:00:00 UTC 2010
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
Molecular and cellular biology
Vascotto C,Fantini D,Romanello M,Cesaratto L,Deganuto M,Leonardi A,Radicella JP,Kelley MR,D'Ambrosio C,Scaloni A,Quadrifoglio F,Tell G
39-6400 was used in immunocytochemistry and western blot to identify APE1 partners
Wed Apr 01 00:00:00 UTC 2009
