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产品信息
PA1-16505
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide derived from the human Ogg1 (within amino acids 1-100).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2156791
产品详细信息
Suggested positive control: Jurkat whole cell extracts.
靶标信息
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-apurinic or apyrimidinic site lyase; N-glycosylase/DNA lyase; OGG1 type 1f
基因别名: HMMH; HOGG1; MMH; MUTM; OGG1; OGH1
UniProt ID: (Human) O15527, (Mouse) O08760, (Rat) O70249
Entrez Gene ID: (Human) 4968, (Mouse) 18294, (Rat) 81528
damaged DNA binding
endonuclease activity
protein binding
microtubule binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
oxidized purine DNA binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
purine-specific mismatch base pair DNA N-glycosylase activity
oxidized base lesion DNA N-glycosylase activity
DNA binding
catalytic activity
DNA-(apurinic or apyrimidinic site) lyase activity
uracil DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
lyase activity
single-strand selective uracil DNA N-glycosylase activity
DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
acute inflammatory response
base-excision repair
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
response to oxidative stress
aging
response to radiation
response to light stimulus
response to estradiol
regulation of protein import into nucleus, translocation
nucleotide-excision repair, DNA incision
response to drug
negative regulation of apoptotic process
depurination
depyrimidination
response to ethanol
response to folic acid
cellular response to cadmium ion
negative regulation of double-strand break repair via single-strand annealing
DNA repair
nucleotide-excision repair
metabolic process
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
