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产品信息
PA5-98030
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Oligophrenin-1 protein (1-270AA)
偶联物
形式
Liquid
浓度
0.18 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812644
靶标信息
Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mental retardation, X-linked 60; Oligophrenin-1; oligophrenin-1, Rho-GTPase activating protein
基因别名: ARHGAP41; MRX60; OPHN1; OPN1
UniProt ID: (Human) O60890
Entrez Gene ID: (Human) 4983
substrate-dependent cell migration, cell extension
signal transduction
nervous system development
axon guidance
actin cytoskeleton organization
regulation of endocytosis
positive regulation of GTPase activity
synaptic vesicle endocytosis
regulation of small GTPase mediated signal transduction
regulation of synaptic transmission, glutamatergic
negative regulation of proteasomal protein catabolic process
