Search Thermo Fisher Scientific
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: nucleolar protein C7; Oxidation resistance protein 1; Protein C7; putative protein product of Nbla00307; TBC/LysM-associated domain containing 3
基因别名: 2210416C20Rik; C7; C7B; Gm1238; Nbla00307; OXR1; TLDC3
UniProt ID: (Human) Q8N573, (Mouse) Q4KMM3, (Rat) Q4V8B0
Entrez Gene ID: (Human) 55074, (Mouse) 170719, (Rat) 117520