Product References
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Nature
Wang D,Townsend LK,DesOrmeaux GJ,Frangos SM,Batchuluun B,Dumont L,Kuhre RE,Ahmadi E,Hu S,Rebalka IA,Gautam J,Jabile MJT,Pileggi CA,Rehal S,Desjardins EM,Tsakiridis EE,Lally JSV,Juracic ES,Tupling AR,Gerstein HC,Paré G,Tsakiridis T,Harper ME,Hawke TJ,Speakman JR,Blondin DP,Holloway GP,Jørgensen SB,Steinberg GR
A-21347 was used in Western Blot to indicate that therapeutic targeting of the GDF15-GFRAL pathway may be useful for maintaining energy expenditure in skeletal muscle during caloric restriction.
Sat Jul 01 00:00:00 UTC 2023
Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis.
Molecules (Basel, Switzerland)
Milchram L,Fischer A,Huber J,Soldo R,Sieghart D,Vierlinger K,Blüml S,Steiner G,Weinhäusel A
A-21347 was used in Protein Assay to identify of antigenic protein biomarkers for rheumatoid arthritis.
Mon Feb 21 00:00:00 UTC 2022
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Nature communications
Inak G,Rybak-Wolf A,Lisowski P,Pentimalli TM,Jüttner R,Glažar P,Uppal K,Bottani E,Brunetti D,Secker C,Zink A,Meierhofer D,Henke MT,Dey M,Ciptasari U,Mlody B,Hahn T,Berruezo-Llacuna M,Karaiskos N,Di Virgilio M,Mayr JA,Wortmann SB,Priller J,Gotthardt M,Jones DP,Mayatepek E,Stenzel W,Diecke S,Kühn R,Wanker EE,Rajewsky N,Schuelke M,Prigione A
A-21347 was used in Western Blot to provide mechanistic insights and suggest potential interventional strategies for a rare mitochondrial disease.
Fri Mar 26 00:00:00 UTC 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Nature communications
Inak G,Rybak-Wolf A,Lisowski P,Pentimalli TM,Jüttner R,Glažar P,Uppal K,Bottani E,Brunetti D,Secker C,Zink A,Meierhofer D,Henke MT,Dey M,Ciptasari U,Mlody B,Hahn T,Berruezo-Llacuna M,Karaiskos N,Di Virgilio M,Mayr JA,Wortmann SB,Priller J,Gotthardt M,Jones DP,Mayatepek E,Stenzel W,Diecke S,Kühn R,Wanker EE,Rajewsky N,Schuelke M,Prigione A
A-21347 was used in Western Blot to provide mechanistic insights and suggest potential interventional strategies for a rare mitochondrial disease.
Fri Mar 26 00:00:00 UTC 2021
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Science translational medicine
Mirali S,Botham A,Voisin V,Xu C,St-Germain J,Sharon D,Hoff FW,Qiu Y,Hurren R,Gronda M,Jitkova Y,Nachmias B,MacLean N,Wang X,Arruda A,Minden MD,Horton TM,Kornblau SM,Chan SM,Bader GD,Raught B,Schimmer AD
A-21347 was used in Western Blotting to show stem cells and acute myeloid leukemia cells can be selectively targeted by inhibition of respiratory chain supercomplex formation.
Wed Apr 08 00:00:00 UTC 2020
Low-load resistance training to task failure with and without blood flow restriction: muscular functional and structural adaptations.
American journal of physiology. Regulatory, integrative and comparative physiology
Pignanelli C,Petrick HL,Keyvani F,Heigenhauser GJF,Quadrilatero J,Holloway GP,Burr JF
A-21347 was used in Western Blotting to examine whole muscle group and skeletal muscle adaptations to 6 weeks of low-load resistance exercise(LL-RE) and low-load blood flow restriction(BFR) resistance exercise(LL-BFR) training to repetition failure.
Sat Feb 01 00:00:00 UTC 2020
Low-load resistance training to task failure with and without blood flow restriction: muscular functional and structural adaptations.
American journal of physiology. Regulatory, integrative and comparative physiology
Pignanelli C,Petrick HL,Keyvani F,Heigenhauser GJF,Quadrilatero J,Holloway GP,Burr JF
A-21347 was used in Western Blotting to examine whole muscle group and skeletal muscle adaptations to 6 weeks of low-load resistance exercise(LL-RE) and low-load blood flow restriction(BFR) resistance exercise(LL-BFR) training to repetition failure.
Sat Feb 01 00:00:00 UTC 2020
LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle.
Oncogenesis
Suh DS,Park SE,Jin H,Lee K,Bae J
Published figure using Complex IV monoclonal antibody (Product # A-21347) in Western Blot
Tue Jan 23 00:00:00 UTC 2018
Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.
Molecular cancer research : MCR
Srinivasan SR,Cesa LC,Li X,Julien O,Zhuang M,Shao H,Chung J,Maillard I,Wells JA,Duckett CS,Gestwicki JE
A-21347 was used in Western Blotting to study the signalling cascade of Hsp70 in the protection against protein degradation.
Mon Jan 01 00:00:00 UTC 2018
HIV-1 promonocytic and lymphoid cell lines: an in vitro model of in vivo mitochondrial and apoptotic lesion.
Journal of cellular and molecular medicine
Morén C,González-Casacuberta I,Álvarez-Fernández C,Bañó M,Catalán-Garcia M,Guitart-Mampel M,Juárez-Flores DL,Tobías E,Milisenda J,Cardellach F,Gatell JM,Sánchez-Palomino S,Garrabou G
A21347 was used in western blot to investigate mitochondrial and apoptotic parameters in chronically human immunodeficiency virus-infected promonocytic and lymphoid cells
Wed Feb 01 00:00:00 UTC 2017
Improved adipose tissue function with initiation of protease inhibitor-only ART.
The Journal of antimicrobial chemotherapy
Maughan RT,Feeney ER,Capel E,Capeau J,Domingo P,Giralt M,Lange JM,Phanuphak P,Cooper DA,Reiss P,Mallon PW
A-21347 was used in western blot to assess the effect of initiating PI-only ART on subcutaneous adipose tissue function in ART-naive subjects
Tue Nov 01 00:00:00 UTC 2016
A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.
Cancer medicine
Reed GA,Schiller GJ,Kambhampati S,Tallman MS,Douer D,Minden MD,Yee KW,Gupta V,Brandwein J,Jitkova Y,Gronda M,Hurren R,Shamas-Din A,Schuh AC,Schimmer AD
A21347 was used in western blot to report the results of a phase 1 dose-escalation study of tigecycline administered to patients with acute myeloid leukemia
Tue Nov 01 00:00:00 UTC 2016
Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells.
BMC cancer
Scott AJ,Wilkinson AS,Wilkinson JC
A-21347 was used in western blot to analyze control of AIF-dependent growth support in pancreatic cancer cells by basal metabolic state
Sat Apr 23 00:00:00 UTC 2016
Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy.
JAMA neurology
Ripolone M,Ronchi D,Violano R,Vallejo D,Fagiolari G,Barca E,Lucchini V,Colombo I,Villa L,Berardinelli A,Balottin U,Morandi L,Mora M,Bordoni A,Fortunato F,Corti S,Parisi D,Toscano A,Sciacco M,DiMauro S,Comi GP,Moggio M
Published figure using OxPhos Complex IV subunit IV monoclonal antibody (Product # A-21347) in Western Blot
Mon Jun 01 00:00:00 UTC 2015
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
Autophagy
Xie W,Zhang L,Jiao H,Guan L,Zha J,Li X,Wu M,Wang Z,Han J,You H
A-21347 was used in western blot to characterize prevention of apoptosis by degrading BBC3/PUMA due to chaperone-mediated autophagy
Mon Jun 20 00:00:00 UTC 2016
Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.
BMC complementary and alternative medicine
Kim TH,Kim JS,Kim ZH,Huang RB,Chae YL,Wang RS
A-21347 was used in western blot to study the effect of Khz-cp, a crude polysaccharide, on cancer growth.
Thu Jul 10 00:00:00 UTC 2014
Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol.
The Journal of physiology
Smith BK,Perry CG,Herbst EA,Ritchie IR,Beaudoin MS,Smith JC,Neufer PD,Wright DC,Holloway GP
A-21347 was used in western blot to study the relationships among submaximal ADP-stimulated respiration rates, ROS generation and skeletal muscle insulin sensitivity in a rat model of type 2 diabetes mellitus.
Sun Dec 01 00:00:00 UTC 2013
Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.
PloS one
Kim TH,Kim Js,Kim Zh,Huang RB,Wang RS
Published figure using Complex IV monoclonal antibody (Product # A-21347) in Western Blot
Tue Apr 02 00:00:00 UTC 2013
The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells.
The Journal of biological chemistry
Lewis EM,Wilkinson AS,Jackson JS,Mehra R,Varambally S,Chinnaiyan AM,Wilkinson JC
A-21347 was used in western blot to examine the contribution of apoptosis-inducing factor to prostate cancer.
Fri Dec 21 00:00:00 UTC 2012
Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species.
Apoptosis : an international journal on programmed cell death
Kim JY,Yu SJ,Oh HJ,Lee JY,Kim Y,Sohn J
A-21347 was used in western blot to elucidate the apoptotic mechanism of panaxydol.
Fri Apr 01 00:00:00 UTC 2011
Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells.
Toxicology and applied pharmacology
Kuo KK,Chen YL,Chen LR,Li CF,Lan YH,Chang FR,Wu YC,Shiue YL
A-21347 was used in western blot to elucidate the upstream apoptotic mechanisms triggered by goniothalamin in hepatocellular carcinoma-derived cells.
Sat Oct 01 00:00:00 UTC 2011
Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis.
Autophagy
Hou W,Han J,Lu C,Goldstein LA,Rabinowich H
A-21347 was used in western blot to study how caspase-8 contributes to cytoprotective autophagic response shifts
Fri Oct 01 00:00:00 UTC 2010
Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.
Cellular signalling
Garibal J,Hollville E,Renouf B,Tétaud C,Wiels J
A-21347 was used in western blot to identify the signal transduction pathways induced by verotoxin treatment
Mon Mar 01 00:00:00 UTC 2010
Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes.
Journal of applied physiology (Bethesda, Md. : 1985)
McConell GK,Ng GP,Phillips M,Ruan Z,Macaulay SL,Wadley GD
A-21347 was used in western blot to test if NOS inhibition reduces mitochondrial biogenesis in response to 5-aminoimidazole-4-carboxamide-ribonucleoside and caffeine
Mon Mar 01 00:00:00 UTC 2010
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex.
Clinical cancer research : an official journal of the American Association for Cancer Research
Trougakos IP,Lourda M,Antonelou MH,Kletsas D,Gorgoulis VG,Papassideri IS,Zou Y,Margaritis LH,Boothman DA,Gonos ES
A-21347 was used in western blot to elucidate the molecular mechanisms of secretory clusterin/apolipoprotein J protein
Thu Jan 01 00:00:00 UTC 2009
PUMA- and Bax-induced autophagy contributes to apoptosis.
Cell death and differentiation
Yee KS,Wilkinson S,James J,Ryan KM,Vousden KH
Published figure using Complex IV monoclonal antibody (Product # A-21347) in Western Blot
Sat Aug 01 00:00:00 UTC 2009
PUMA- and Bax-induced autophagy contributes to apoptosis.
Cell death and differentiation
Yee KS,Wilkinson S,James J,Ryan KM,Vousden KH
Published figure using Complex IV monoclonal antibody (Product # A-21347) in Western Blot
Sat Aug 01 00:00:00 UTC 2009
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.
Carcinogenesis
Kutuk O,Arisan ED,Tezil T,Shoshan MC,Basaga H
A-21347 was used in western blot to elucidate how cisplatin overcomes Bcl-2-mediated protection against apoptosis
Tue Sep 01 00:00:00 UTC 2009
Contribution of membrane localization to the apoptotic activity of PUMA.
Apoptosis : an international journal on programmed cell death
Yee KS,Vousden KH
A-21347 was used in western blot to assess the contribution of different regions of PUMA to its localization and function
Tue Jan 01 00:00:00 UTC 2008
Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins.
The Journal of pharmacology and experimental therapeutics
Castello PR,Drechsel DA,Day BJ,Patel M
A-21347 was used in western blot to design an in vitro assay to detect endogenously released hydrogen peroxide and identify glyoxylate metalloporphyrins in rat brain mitochondria
Sat Mar 01 00:00:00 UTC 2008
Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei.
Journal of cancer research and clinical oncology
Sibayama-Imazu T,Fujisawa Y,Masuda Y,Aiuchi T,Nakajo S,Itabe H,Nakaya K
A-21347 was used in western blot to elucidate the mechanism of vitamin K-induced apoptosis
Tue Jul 01 00:00:00 UTC 2008
Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway.
Journal of virology
Martin-Latil S,Mousson L,Autret A,Colbère-Garapin F,Blondel B
A-21347 was used in western blot to study the activation of Bax during rotavirus-induced apoptosis.
Tue May 01 00:00:00 UTC 2007
Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase.
Journal of virology
Autret A,Martin-Latil S,Mousson L,Wirotius A,Petit F,Arnoult D,Colbère-Garapin F,Estaquier J,Blondel B
A-21347 was used in western blot to report that poliovirus induces mitochondrial cytochrome c release and loss of mitochondrial transmembrane potential in infected neurons
Sun Jul 01 00:00:00 UTC 2007
Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain.
The Journal of biological chemistry
Castello PR,Drechsel DA,Patel M
A-21347 was used in western blot to study the involvement of brain mitochondria in Paraquat-induced reactive oxygen species production in Parkinson's disease models
Fri May 11 00:00:00 UTC 2007
Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress.
The Journal of biological chemistry
Ishihara Y,Shimamoto N
A-21347 was used in western blot to study sustained endogenous oxidative stress and the involvement of endonuclease G in nucleosomal DNA fragmentation
Fri Mar 10 00:00:00 UTC 2006
Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I.
The Journal of biological chemistry
Iuso A,Scacco S,Piccoli C,Bellomo F,Petruzzella V,Trentadue R,Minuto M,Ripoli M,Capitanio N,Zeviani M,Papa S
A-21347 was used in western blot to study patients with mutations in the NDUFS1 and NDUFS4 genes of complex 1 and the dysfunction of cellular oxidative metabolism
Fri Apr 14 00:00:00 UTC 2006
Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria.
The Journal of biological chemistry
Brown MR,Sullivan PG,Geddes JW
A-21347 was used in western blot to study susceptibility to Ca2+ overload in synaptic mitochondria more than nonsynaptic mitochondria
Fri Apr 28 00:00:00 UTC 2006
A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways.
Proceedings of the National Academy of Sciences of the United States of America
Boehning D,van Rossum DB,Patterson RL,Snyder SH
A-21347 was used in western blot to characterize the interaction between cytochrome c and inositol 1,4,5-trisphosphate receptor
Tue Feb 01 00:00:00 UTC 2005
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Science (New York, N.Y.)
Lustbader JW,Cirilli M,Lin C,Xu HW,Takuma K,Wang N,Caspersen C,Chen X,Pollak S,Chaney M,Trinchese F,Liu S,Gunn-Moore F,Lue LF,Walker DG,Kuppusamy P,Zewier ZL,Arancio O,Stern D,Yan SS,Wu H
A-21347 was used in western blot to study the direct link between Abeta to mitochondrial toxicity in Alzheimer's disease by ABAD
Fri Apr 16 00:00:00 UTC 2004
Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Plesnila N,Zhu C,Culmsee C,Gröger M,Moskowitz MA,Blomgren K
A-21347 was used in immunohistochemistry - paraffin section to test if AIF contributes to cell death after focal cerebral ischemia
Thu Apr 01 00:00:00 UTC 2004
Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.
The Journal of biological chemistry
Masuda Y,Shima G,Aiuchi T,Horie M,Hori K,Nakajo S,Kajimoto S,Shibayama-Imazu T,Nakaya K
A-21347 was used in Western Blotting to study the mechanisms by which beta-Hydroxyisovalerylshikonin induces apoptosis.
Fri Oct 08 00:00:00 UTC 2004
Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.
The Journal of biological chemistry
Masuda Y,Shima G,Aiuchi T,Horie M,Hori K,Nakajo S,Kajimoto S,Shibayama-Imazu T,Nakaya K
A-21347 was used in Western Blotting to study the mechanisms by which beta-Hydroxyisovalerylshikonin induces apoptosis.
Fri Oct 08 00:00:00 UTC 2004
Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins.
The Journal of biological chemistry
Thomenius MJ,Wang NS,Reineks EZ,Wang Z,Distelhorst CW
A-21347 was used in immunocytochemistry to analyze regulation of Bax activity by binding to BH3-only proteins by Bcl-2 on the endoplasmic reticulum
Fri Feb 21 00:00:00 UTC 2003
Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics.
The Journal of biological chemistry
Walzel B,Speer O,Zanolla E,Eriksson O,Bernardi P,Wallimann T
A-21347 was used in immunohistochemistry - paraffin section to investigate creatine localization and transport in the mitochondria
Fri Oct 04 00:00:00 UTC 2002
Optical imaging techniques (histochemical, immunohistochemical, and in situ hybridization staining methods) to visualize mitochondria.
Methods in cell biology
Tanji K,Bonilla E
A-21347 was used in immunohistochemistry - frozen section to use optical imaging techniques to visualize mitochondria
Tue Dec 04 00:00:00 UTC 2001
Synergistic movements of Ca(2+) and Bax in cells undergoing apoptosis.
The Journal of biological chemistry
Pan Z,Bhat MB,Nieminen AL,Ma J
A-21347 was used in immunocytochemistry to elucidate how calcium and Bax coordinate the initiation of apoptosis
Fri Aug 24 00:00:00 UTC 2001
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis.
The Journal of cell biology
Griffiths GJ,Dubrez L,Morgan CP,Jones NA,Whitehouse J,Corfe BM,Dive C,Hickman JA
A-21347 was used in western blot to discover that a concealed NH2-terminal epitope of Bak is exposed in vivo before apoptosis
Mon Mar 08 00:00:00 UTC 1999
Expression of mtDNA and nDNA encoded respiratory chain proteins in chemically and genetically-derived Rho0 human fibroblasts: a comparison of subunit proteins in normal fibroblasts treated with ethidium bromide and fibroblasts from a patient with mtDNA depletion syndrome.
Biochimica et biophysica acta
Marusich MF,Robinson BH,Taanman JW,Kim SJ,Schillace R,Smith JL,Capaldi RA
A-21347 was used in western blot to determine the subunit expression patterns of respiratory chain enzyme complexes II and IV in cultured cells lacking mitochondrial DNA
Wed Dec 31 00:00:00 UTC 1997
Subunit specific monoclonal antibodies show different steady-state levels of various cytochrome-c oxidase subunits in chronic progressive external ophthalmoplegia.
Biochimica et biophysica acta
Taanman JW,Burton MD,Marusich MF,Kennaway NG,Capaldi RA
A-21347 was used in western blot to generate monoclonal antibodies that recognize mitochondrial- and nuclear-encoded subunits of human cytochrome-c oxidase
Fri Apr 12 00:00:00 UTC 1996
Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells.
Methods in enzymology
Capaldi RA,Marusich MF,Taanman JW
A-21347 was used in western blot to Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells
Mon Apr 01 00:00:00 UTC 1996
KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria.
Cell
Nangaku M,Sato-Yoshitake R,Okada Y,Noda Y,Takemura R,Yamazaki H,Hirokawa N
A-21347 was used in western blot to propose that KIF1B is a monomeric motor for anterograde transport of mitochondria
Fri Dec 30 00:00:00 UTC 1994
