Product References
RINT1 deficiency disrupts lipid metabolism and underlies a complex hereditary spastic paraplegia.
The Journal of clinical investigation
Launay N,Ruiz M,Planas-Serra L,Verdura E,Rodríguez-Palmero A,Schlüter A,Goicoechea L,Guilera C,Casas J,Campelo F,Jouanguy E,Casanova JL,Boespflug-Tanguy O,Vazquez Cancela M,Gutiérrez-Solana LG,Casasnovas C,Area-Gomez E,Pujol A
A21348 was used in Western Blot to highlight the pivotal role of RINT1 in lipid metabolism and mitochondria function, with a profound effect in central nervous system development.
Mon Jul 17 00:00:00 UTC 2023
The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins.
Cancers
Rupprecht A,Theisen U,Wendt F,Frank M,Hinz B
A21348 was used in Western Blotting to describe a previously unknown mitochondria-targeting mechanism behind the toxic effect of THC and CBD on glioblastoma cells that should be considered in future cancer therapy, especially in combination strategies with other chemotherapeutics.
Mon Jun 27 00:00:00 UTC 2022
Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise.
Nature communications
Koh JH,Pataky MW,Dasari S,Klaus KA,Vuckovic I,Ruegsegger GN,Kumar AP,Robinson MM,Nair KS
A21348 was used in Western Blotting to provide a mechanistic link between RET and improved glucose metabolism, offering an important therapeutic target to counteract aging and inactivity-induced metabolic diseases benefitting those who cannot exercise due to many reasons.
Thu Apr 28 00:00:00 UTC 2022
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.
Nature communications
Mise S,Matsumoto A,Shimada K,Hosaka T,Takahashi M,Ichihara K,Shimizu H,Shiraishi C,Saito D,Suyama M,Yasuda T,Ide T,Izumi Y,Bamba T,Kimura-Someya T,Shirouzu M,Miyata H,Ikawa M,Nakayama KI
A21348 was used in Western Blot to identify two sperm-specific polypeptides, Kastor and Polluks, encoded by a single mouse locus (Gm9999) previously annotated as encoding a lncRNA.
Mon Feb 28 00:00:00 UTC 2022
Do Extracellular Vesicles Derived from Mesenchymal Stem Cells Contain Functional Mitochondria?
International journal of molecular sciences
Zorova LD,Kovalchuk SI,Popkov VA,Chernikov VP,Zharikova AA,Khutornenko AA,Zorov SD,Plokhikh KS,Zinovkin RA,Evtushenko EA,Babenko VA,Pevzner IB,Shevtsova YA,Goryunov KV,Plotnikov EY,Silachev DN,Sukhikh GT,Zorov DB
A21348 was used in Western Blotting to demonstrate that the EV contain all parts of mitochondria; however, their independent functionality inside EV has not been confirmed, which may be due either to the absence of necessary cofactors and/or the EV formation process and, probably the methodology of obtaining EV.
Sun Jul 03 00:00:00 UTC 2022
Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats.
International journal of molecular sciences
Andrianova NV,Zorova LD,Pevzner IB,Kolosova NG,Plotnikov EY,Zorov DB
A21348 was used in Western Blotting to assess the levels of anti- and proapoptotic proteins of the Bcl-2 family, COX IV, GAPDH, and mitochondrial deacetylase SIRT-3, as well as alterations in total protein acetylation and carbonylation, mitochondrial dynamics (OPA1, Fis1, Drp1) and kidney regeneration pathways (PCNA, GDF11).
Sat Dec 03 00:00:00 UTC 2022
Isolation of Exosome-Enriched Extracellular Vesicles Carrying Granulocyte-Macrophage Colony-Stimulating Factor from Embryonic Stem Cells.
Journal of visualized experiments : JoVE
Meng S,Whitt AG,Tu A,Eaton JW,Li C,Yaddanapudi K
A21348 was used in Western Blotting to suggest that GM-CSF-bearing exosome-enriched EVs from ESCs might function as cell-free vesicles to exert their immune-regulatory activities.
Thu Nov 11 00:00:00 UTC 2021
Delineating the Switch between Senescence and Apoptosis in Cervical Cancer Cells under Ciclopirox Treatment.
Cancers
Herrmann AL,Kuhn BJ,Holzer A,Krijgsveld J,Hoppe-Seyler K,Hoppe-Seyler F
A21348 was used in Western Blot to reveal that the phenotypic response of cervical cancer cells towards CPX is strongly dependent on glucose availability, link the pro-apoptotic and pro-senescent activities of CPX to its bifunctionality as an OXPHOS inhibitor and iron chelator, respectively, and provide a rationale for combining CPX with glycolysis inhibitors.
Tue Oct 05 00:00:00 UTC 2021
Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice.
Redox biology
Onoki T,Izumi Y,Takahashi M,Murakami S,Matsumaru D,Ohta N,Wati SM,Hatanaka N,Katsuoka F,Okutsu M,Yabe Y,Hagiwara Y,Kanzaki M,Bamba T,Itoi E,Motohashi H
A21348 was used in Western Blot to indicate that NRF2 activation in skeletal muscles promotes communication with adipose tissues via humoral and/or neuronal signaling and facilitates the utilization of fatty acids as an energy source, resulting in increased mitochondrial activity and efficient energy production during exercise, which leads to improved exercise endurance.
Thu Jul 01 00:00:00 UTC 2021
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
Cancers
Barés G,Beà A,Hernández L,Navaridas R,Felip I,Megino C,Blasco N,Nadeu F,Campo E,Llovera M,Dolcet X,Sanchis D
A21348 was used in Western Blot to investigate the effect of ENDOG/Endog expression on proliferation in different tumor models.
Wed Jul 28 00:00:00 UTC 2021
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
Cancers
Barés G,Beà A,Hernández L,Navaridas R,Felip I,Megino C,Blasco N,Nadeu F,Campo E,Llovera M,Dolcet X,Sanchis D
A21348 was used in Western Blot to investigate the effect of ENDOG/Endog expression on proliferation in different tumor models.
Wed Jul 28 00:00:00 UTC 2021
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Nature cell biology
Rey T,Zaganelli S,Cuillery E,Vartholomaiou E,Croisier M,Martinou JC,Manley S
A21348 was used in Western Blot, Immunocytochemistry to investigate the internal architecture of MRGs using fluorescence super-resolution localization microscopy and correlative electron microscopy, and found that the MRG ultrastructure consists of compacted RNA embedded within a protein cloud.
Thu Oct 01 00:00:00 UTC 2020
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Nature cell biology
Rey T,Zaganelli S,Cuillery E,Vartholomaiou E,Croisier M,Martinou JC,Manley S
A21348 was used in Western Blot, Immunocytochemistry to investigate the internal architecture of MRGs using fluorescence super-resolution localization microscopy and correlative electron microscopy, and found that the MRG ultrastructure consists of compacted RNA embedded within a protein cloud.
Thu Oct 01 00:00:00 UTC 2020
Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes.
Autophagy
Hase K,Contu VR,Kabuta C,Sakai R,Takahashi M,Kataoka N,Hakuno F,Takahashi SI,Fujiwara Y,Wada K,Kabuta T
A21348 was used in Western Blotting to identify the importance of nucleic acid-binding capacity of SIDT2 for its function in translocating nucleic acids into lysosomes.
Sun Nov 01 00:00:00 UTC 2020
Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction.
Diabetes
Wende AR,Schell JC,Ha CM,Pepin ME,Khalimonchuk O,Schwertz H,Pereira RO,Brahma MK,Tuinei J,Contreras-Ferrat A,Wang L,Andrizzi CA,Olsen CD,Bradley WE,Dell'Italia LJ,Dillmann WH,Litwin SE,Abel ED
A21348 was used in Western Blotting to identify mitochondria as a major target of glucotoxicity.
Thu Oct 01 00:00:00 UTC 2020
Aging alters acetylation status in skeletal and cardiac muscles.
GeroScience
Yeo D,Kang C,Ji LL
A21348 was used in Western Blotting to suggest that despite the upregulation of SIRTs, aged muscles suffered from NAD+ deficit partly due to the competition of elevated CD38 and PARP-1.
Mon Jun 01 00:00:00 UTC 2020
Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models.
The Journal of nutritional biochemistry
Morrell A,Tripet BP,Eilers BJ,Tegman M,Thompson D,Copié V,Burkhead JL
A21348 was used in Western Blotting to characterize the impact of dietary copper on the biochemical and hepatic metabolite changes associated with fructose toxicity in a Wistar rat model of fructose-induced liver disease.
Wed Apr 01 00:00:00 UTC 2020
DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism.
Human molecular genetics
Maresca A,Del Dotto V,Capristo M,Scimonelli E,Tagliavini F,Morandi L,Tropeano CV,Caporali L,Mohamed S,Roberti M,Scandiffio L,Zaffagnini M,Rossi J,Cappelletti M,Musiani F,Contin M,Riva R,Liguori R,Pizza F,La Morgia C,Antelmi E,Loguercio Polosa P,Mignot E,Zanna C,Plazzi G,Carelli V
A21348 was used in Western Blotting to show that DNMT1 is not localized within mitochondria, but it is associated with the mitochondrial outer membrane.
Tue Jul 21 00:00:00 UTC 2020
Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species.
Redox biology
Blasco N,Beà A,Barés G,Girón C,Navaridas R,Irazoki A,López-Lluch G,Zorzano A,Dolcet X,Llovera M,Sanchis D
A21348 was used in Western Blotting to investigate the role of EndoG in cell proliferation.
Thu Oct 01 00:00:00 UTC 2020
Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson's Disease Model.
Oxidative medicine and cellular longevity
Han J,Kim SJ,Ryu MJ,Jang Y,Lee MJ,Ju X,Lee YL,Cui J,Shong M,Heo JY,Kweon GR
A21348 was used in Western Blotting to show chloramphenicol in a toxin-induced Parkinson's Disease model mediates inhibition of mitochondrial complex I in dopaminergic neurons leading to mitigation of oxidative stress.
Fri Mar 20 00:00:00 UTC 2020
Neurofascin (NFASC) gene mutation causes autosomal recessive ataxia with demyelinating neuropathy.
Parkinsonism & related disorders
Monfrini E,Straniero L,Bonato S,Monzio Compagnoni G,Bordoni A,Dilena R,Rinchetti P,Silipigni R,Ronchi D,Corti S,Comi GP,Bresolin N,Duga S,Di Fonzo A
A21348 was used in Western Blotting to identify a homozygous p.V1122E mutation in NFASC, leading to early-onset cerebellar ataxia and demyelinating neuropathy in an Italian family, highlighting nodopathies associated with hereditary ataxia syndrome with neuropathy.
Sat Jun 01 00:00:00 UTC 2019
Exosomes from GM-CSF expressing embryonic stem cells are an effective prophylactic vaccine for cancer prevention.
Oncoimmunology
Yaddanapudi K,Meng S,Whitt AG,Al Rayyan N,Richie J,Tu A,Eaton JW,Li C
A21348 was used in Western Blot to conclude that a similar vaccine derived from GM-CSF- expressing human ESCs can be employed as a preventative vaccine for humans with an increased risk of developing cancer.
Tue Jan 12 00:00:00 UTC 2021
Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.
Brain pathology (Zurich, Switzerland)
Ruiz M,Bégou M,Launay N,Ranea-Robles P,Bianchi P,López-Erauskin J,Morató L,Guilera C,Petit B,Vaurs-Barriere C,Guéret-Gonthier C,Bonnet-Dupeyron MN,Fourcade S,Auwerx J,Boespflug-Tanguy O,Pujol A
A21348 was used in Western Blotting to examine the link between redox and metabolic homeostasis in myelin diseases.
Sat Sep 01 00:00:00 UTC 2018
Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency.
Cell reports
Stein CS,Jadiya P,Zhang X,McLendon JM,Abouassaly GM,Witmer NH,Anderson EJ,Elrod JW,Boudreau RL
A21348 was used in Western Blotting to show that a skeletal muscle- and heart-enriched long non-coding RNA, LINC00116, encodes a highly conserved 56-amino-acid microprotein, mitoregulin.
Tue Jun 26 00:00:00 UTC 2018
APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress.
Cell death & disease
Pan JX,Tang F,Xiong F,Xiong L,Zeng P,Wang B,Zhao K,Guo H,Shun C,Xia WF,Mei L,Xiong WC
A21348 was used in Western Blot to identify the function of amyloid precursor protein (APP) in promoting osteoblast survival and bone formation.
Mon Oct 22 00:00:00 UTC 2018
PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise.
Cell metabolism
Koh JH,Hancock CR,Terada S,Higashida K,Holloszy JO,Han DH
A21348 was used in Western Blotting to demonstrate that PPARΒ plays essential roles in the maintenance and adaptive increase in mitochondrial enzymes in skeletal muscle by exercise.
Tue May 02 00:00:00 UTC 2017
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
The Journal of cell biology
Schatton D,Pla-Martin D,Marx MC,Hansen H,Mourier A,Nemazanyy I,Pessia A,Zentis P,Corona T,Kondylis V,Barth E,Schauss AC,Velagapudi V,Rugarli EI
A21348 was used in western blot to identify posttranscriptional mechanisms that regulate mitochondrial protein expression
Mon Mar 06 00:00:00 UTC 2017
The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation.
Stem cells (Dayton, Ohio)
Wanet A,Caruso M,Domelevo Entfellner JB,Najar M,Fattaccioli A,Demazy C,Evraerts J,El-Kehdy H,Pourcher G,Sokal E,Arnould T,Tiffin N,Najimi M,Renard P
A21348 was used in Western Blotting to identify a transcriptional regulatory axis, coupling the loss of pluripotency and early commitment to differentiation, to the initiation of mitochondrial biogenesis and metabolic shift toward oxidative phosphorylation.
Sun Oct 01 00:00:00 UTC 2017
Fatty acid oxidation in macrophage polarization.
Nature immunology
Nomura M,Liu J,Rovira II,Gonzalez-Hurtado E,Lee J,Wolfgang MJ,Finkel T
A21348 was used in western blot to characterize macrophage polarization with fatty acid oxidation
Tue Mar 01 00:00:00 UTC 2016
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.
The Journal of physiology
Spendiff S,Vuda M,Gouspillou G,Aare S,Perez A,Morais JA,Jagoe RT,Filion ME,Glicksman R,Kapchinsky S,MacMillan NJ,Pion CH,Aubertin-Leheudre M,Hettwer S,Correa JA,Taivassalo T,Hepple RT
A21348 was used in western blot to clarify the role of denervation in modulating mitochondrial function in ageing muscle
Thu Dec 15 00:00:00 UTC 2016
Lactate's effect on human neuroblastoma cell bioenergetic fluxes.
Biochemical pharmacology
E L,Swerdlow RH
A21348 was used in western blot to investigate how lactate affects neuron metabolism
Fri Jan 01 00:00:00 UTC 2016
Long time remodeling during retinal degeneration evaluated by optical coherence tomography, immunocytochemistry and fundus autofluorescence.
Experimental eye research
Pinilla I,Fernández-Sánchez L,Segura FJ,Sánchez-Cano AI,Tamarit JM,Fuentes-Broto L,Eells JT,Lax P,Cuenca N
A21348 was used in Immunohistochemistry to characterize the relationship between fundus autofluorescence (FAF), Optical Coherence Tomography (OCT) and immunohistochemistry (IHC) over the course of chronic retinal degeneration in the P23H rat.
Thu Sep 01 00:00:00 UTC 2016
Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.
Redox biology
Smith MR,Vayalil PK,Zhou F,Benavides GA,Beggs RR,Golzarian H,Nijampatnam B,Oliver PG,Smith RA,Murphy MP,Velu SE,Landar A
A21348 was used in Western Blotting to show that modification of mitochondrial protein thiols by a model compound IBTP decreased mitochondrial metabolism and ATP in MDA-MB 231 breast adenocarcinoma cells up to 6 days after an initial 24h treatment.
Mon Aug 01 00:00:00 UTC 2016
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation.
Biochemical pharmacology
Mattiolo P,Yuste VJ,Boix J,Ribas J
A21348 was used in western blot to discuss the role of autophagy in cell death.
Tue Dec 15 00:00:00 UTC 2015
Mechanical Overloading Increases Maximal Force and Reduces Fragility in Hind Limb Skeletal Muscle from Mdx Mouse.
The American journal of pathology
Ferry A,Parlakian A,Joanne P,Fraysse B,Mgrditchian T,Roy P,Furling D,Butler-Browne G,Agbulut O
A21348 was used in western blot to test the effects of mechanical overloading using a murine model of Duchene muscular dystrophy.
Wed Jul 01 00:00:00 UTC 2015
Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response.
Mitochondrion
Michel S,Canonne M,Arnould T,Renard P
A21348 was used in western blot to demonstrate that altered/impaired expression of mtDNA induces CHOP-10 expression dependent on the eIF2α/ATF4 axis of the integrated stress response.
Sun Mar 01 00:00:00 UTC 2015
Acetyl CoA carboxylase inactivation and meiotic maturation in mouse oocytes.
Molecular reproduction and development
Valsangkar DS,Downs SM
A21348 was used in Immunocytochemistry to support the model that ACAC inactivation contributes to the maturation-promoting activity of PRKA through stimulation of FAO.
Tue Sep 01 00:00:00 UTC 2015
Mitochondrial remodeling in hepatic differentiation and dedifferentiation.
The international journal of biochemistry & cell biology
Wanet A,Remacle N,Najar M,Sokal E,Arnould T,Najimi M,Renard P
A21348 was used in western blot to describe mitochondrial biogenesis during hepatogenic differentiation of bone marrow-mesenchymal stem cells
Mon Sep 01 00:00:00 UTC 2014
Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation.
Neurobiology of aging
E L,Burns JM,Swerdlow RH
A21348 was used in western blot to determine how intensive exercise affects brain bioenergetics, inflammation, and neurogenesis-relevant parameters
Sat Nov 01 00:00:00 UTC 2014
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
Carcinogenesis
Wang CL,Wang JY,Liu ZY,Ma XM,Wang XW,Jin H,Zhang XP,Fu D,Hou LJ,Lu YC
A21348 was used in western blot to study the relationship between USP2-MDM4 and p53 in tumorigenesis
Tue Jul 01 00:00:00 UTC 2014
Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis.
Toxicology
Watanabe M,Funakoshi T,Unuma K,Aki T,Uemura K
A21348 was used in western blot to assess the role of Parkin against cardiotoxicity elicited by arsenic trioxide exposure in HL-1 mouse atrial cardiomyocytes
Fri Aug 01 00:00:00 UTC 2014
Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.
Molecular vision
de Andrade GB,Kunzelman L,Merrill MM,Fuerst PG
A21348 was used in immunohistochemistry to study the role of down syndrome cell adhesion molecule during mice retina development
Fri Jun 26 00:00:00 UTC 2015
A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.
The Journal of biological chemistry
Laker RC,Xu P,Ryall KA,Sujkowski A,Kenwood BM,Chain KH,Zhang M,Royal MA,Hoehn KL,Driscoll M,Adler PN,Wessells RJ,Saucerman JJ,Yan Z
A21348 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to generate tools to assess mitochondrial health in vivo.
Fri Apr 25 00:00:00 UTC 2014
The membrane-active tri-block copolymer pluronic F-68 profoundly rescues rat hippocampal neurons from oxygen-glucose deprivation-induced death through early inhibition of apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shelat PB,Plant LD,Wang JC,Lee E,Marks JD
A21348 was used in Western Blotting to demonstrate the efficacy of Pluronic F-68 in rescuing rat hippocampal neurons from apoptosis after oxygen-glucose deprivation.
Wed Jul 24 00:00:00 UTC 2013
β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle.
American journal of physiology. Endocrinology and metabolism
Kim SH,Asaka M,Higashida K,Takahashi Y,Holloszy JO,Han DH
A21348 was used in western blot to test if the increases in PGC-α and mitochondrial biogenesis induced by endurance exercise are mediated by catecholamines.
Mon Apr 15 00:00:00 UTC 2013
Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation.
American journal of physiology. Cell physiology
Wallace MA,Russell AP
A21348 was used in western blot to test if STARS influences C2C2 myotube growth by regulating protein synthesis and degradation.
Thu Aug 15 00:00:00 UTC 2013
Effect of exercise on mouse liver and brain bioenergetic infrastructures.
Experimental physiology
E L,Lu J,Burns JM,Swerdlow RH
A21348 was used in western blot to examine the effects of exercise on liver and brain bioenergetic infrastructures.
Tue Jan 01 00:00:00 UTC 2013
Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis.
The Journal of biological chemistry
Menzies KJ,Singh K,Saleem A,Hood DA
A21348 was used in western blot to determine the role of sirtuin in exercise- and resveratrol-induced skeletal muscle mitochondrial biogenesis.
Fri Mar 08 00:00:00 UTC 2013
An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis.
Journal of proteomics
Karhemo PR,Ravela S,Laakso M,Ritamo I,Tatti O,Mäkinen S,Goodison S,Stenman UH,Hölttä E,Hautaniemi S,Valmu L,Lehti K,Laakkonen P
A21348 was used in Western Blot to study novel metastasis-associated proteins from an isogenic pair of human MDA-MB-435 cancer cells with opposite metastatic phenotypes.
Fri Dec 21 00:00:00 UTC 2012
Oxidative capacity and fatigability in run-trained malignant hyperthermia-susceptible mice.
Muscle & nerve
Rouviere C,Corona BT,Ingalls CP
A21348 was used in western blot to test if the malignant hyperthermia model mice are more vulnerable to exercise-induced muscle injury and fatigability.
Sun Apr 01 00:00:00 UTC 2012
Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D.
Biochimica et biophysica acta
Li B,Chauvin C,De Paulis D,De Oliveira F,Gharib A,Vial G,Lablanche S,Leverve X,Bernardi P,Ovize M,Fontaine E
A21348 was used in western blot to study the effect of different inhibitors on mitochondrial permeability transition pore.
Sat Sep 01 00:00:00 UTC 2012
Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes.
PloS one
Kiss K,Brozik A,Kucsma N,Toth A,Gera M,Berry L,Vallentin A,Vial H,Vidal M,Szakacs G
A21348 was used in western blot to question the expression and function of ABCB6 in the mitochondria.
Thu Sep 27 00:00:00 UTC 2012
Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina.
Neurobiology of disease
Esteve-Rudd J,Fernández-Sánchez L,Lax P,De Juan E,Martín-Nieto J,Cuenca N
A21348 was used in immunohistochemistry to determine the effects of rotenone treatment in the retina.
Sat Oct 01 00:00:00 UTC 2011
The importance of PGC-1α in contractile activity-induced mitochondrial adaptations.
American journal of physiology. Endocrinology and metabolism
Uguccioni G,Hood DA
A21348 was used in western blot to investigate the role of PGC-1alpha in organelle biogenesis
Tue Feb 01 00:00:00 UTC 2011
Alternate day fasting impacts the brain insulin-signaling pathway of young adult male C57BL/6 mice.
Journal of neurochemistry
Lu J,E L,Wang W,Frontera J,Zhu H,Wang WT,Lee P,Choi IY,Brooks WM,Burns JM,Aires D,Swerdlow RH
A21348 was used in Western Blotting to investigate how dietary restriction affects bioenergetics-relevant enzymes and signalling pathways in the brain.
Fri Apr 01 00:00:00 UTC 2011
Heterogeneous levels of oxidative phosphorylation enzymes in rat adrenal glands.
Acta histochemica
Ogawa K,Harada K,Endo Y,Sagawa S,Inoue M
A21348 was used in immunohistochemistry - paraffin section and western blot to observe and characterize mitochondria in the rat adrenal gland
Sat Jan 01 00:00:00 UTC 2011
Polymorphic variation in cytochrome oxidase subunit genes.
Journal of Alzheimer's disease : JAD
Lu J,Wang K,Rodova M,Esteves R,Berry D,E L,Crafter A,Barrett M,Cardoso SM,Onyango I,Parker WD,Fontes J,Burns JM,Swerdlow RH
A21348 was used in western blot to investigate genetic variability of cytochrome oxidase
Tue Nov 02 00:00:00 UTC 2010
Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Weisová P,Concannon CG,Devocelle M,Prehn JH,Ward MW
A21348 was used in western blot to study AMPK activation and its regulation of cell surface GLUT3 expression in neuronal tolerance to excitotoxicity
Wed Mar 04 00:00:00 UTC 2009
Cellular adaptations in soleus muscle during recovery after hindlimb unloading.
Acta physiologica (Oxford, England)
Oishi Y,Ogata T,Yamamoto KI,Terada M,Ohira T,Ohira Y,Taniguchi K,Roy RR
A21348 was used in western blot to study the apoptotic responses associated with soleus muscle atrophy and subsequent recovery
Sat Mar 01 00:00:00 UTC 2008
Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology
Jin JK,Whittaker R,Glassy MS,Barlow SB,Gottlieb RA,Glembotski CC
A21348 was used in western blot to test if protection from heart I/R damage by P-alphaBC-S59 is mediated by its localization to mitochondria
Tue Jan 01 00:00:00 UTC 2008
cGMP rescues mitochondrial dysfunction induced by glucose and insulin in myocytes.
Biochemical and biophysical research communications
Mitsuishi M,Miyashita K,Itoh H
A21348 was used in western blot to test if cGMP rescues mitochondrial dysfunction in C2C12 myotubular cells induced high-glucose and high-insulin conditions
Fri Mar 21 00:00:00 UTC 2008
Cytochrome C oxidase activity and oxygen tolerance.
The Journal of biological chemistry
Campian JL,Gao X,Qian M,Eaton JW
A21348 was used in western blot to characterize oxygen tolerance and cytochrome C oxidase activity
Fri Apr 27 00:00:00 UTC 2007
Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Endo H,Kamada H,Nito C,Nishi T,Chan PH
A21348 was used in western blot to elucidate how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischemia
Wed Jul 26 00:00:00 UTC 2006
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.
Carcinogenesis
Xiao D,Lew KL,Zeng Y,Xiao H,Marynowski SW,Dhir R,Singh SV
A21348 was used in Western Blot to study the molecular mechanism of apoptosis induction by phenethyl isothiocyanate using PC-3 human prostate cancer cells as a model.
Wed Nov 01 00:00:00 UTC 2006
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells.
The Journal of biological chemistry
Ming L,Wang P,Bank A,Yu J,Zhang L
A21348 was used in western blot to analyze induction of apoptosis in colon cancer cells by PUMA dissociating Bcl-X(L) and Bax
Fri Jun 09 00:00:00 UTC 2006
Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.
Molecular and cellular biology
Wong HK,Fricker M,Wyttenbach A,Villunger A,Michalak EM,Strasser A,Tolkovsky AM
A21348 was used in western blot to investigate the role of the p53 and JNK/c-Jun pathways in the activation of BH3-only proteins
Sat Oct 01 00:00:00 UTC 2005
Soy isoflavones modulate the expression of BAD and neuron-specific beta III tubulin in male rat brain.
Neuroscience letters
Bu L,Lephart ED
A21348 was used in western blot to examine the effects of soy isoflavones on markers of neuronal apoptosis and survival in vivo
Fri Sep 09 00:00:00 UTC 2005
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes.
The Journal of biological chemistry
Shi T,Wang F,Stieren E,Tong Q
A21348 was used in Western Blotting to demonstrate that SIRT3 activates mitochondria functions and plays an important role in adaptive thermogenesis in brown adipose.
Fri Apr 08 00:00:00 UTC 2005
Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia.
Stroke
Lee SH,Kwon HM,Kim YJ,Lee KM,Kim M,Yoon BW
A21348 was used in Western Blotting to suggest that the deletion of the hsp70.1 gene increases cytochrome c release into the cytoplasm and subsequent caspase-3 activation.
Wed Sep 01 00:00:00 UTC 2004
Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Zhao H,Yenari MA,Cheng D,Barreto-Chang OL,Sapolsky RM,Steinberg GK
A21348 was used in Western Blotting to suggest that AIF translocated into nuclei after cytochrome c was released into the cytosol.
Tue Jun 01 00:00:00 UTC 2004
Metabolic dysfunction and depletion of mitochondria in hearts of septic rats.
Journal of molecular and cellular cardiology
Watts JA,Kline JA,Thornton LR,Grattan RM,Brar SS
A21348 was used in western blot to test if there are changes in cardiac mitochondrial content and caspase activation during sepsis
Thu Jan 01 00:00:00 UTC 2004
Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression.
American journal of physiology. Heart and circulatory physiology
Engel D,Peshock R,Armstong RC,Sivasubramanian N,Mann DL
A21348 was used in Western Blot to study the effect of cardiac myocyte apoptosis on the transition from a hypertrophic to a dilated cardiac phenotype.
Wed Sep 01 00:00:00 UTC 2004
Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release.
Molecular biology of the cell
Kim TH,Zhao Y,Ding WX,Shin JN,He X,Seo YW,Chen J,Rabinowich H,Amoscato AA,Yin XM
A21348 was used in western blot to assess the contribution to mitochondrial cytochrome C release and cristae reorganization by Bid-cardiolipin interaction at mitochondrial contact site
Thu Jul 01 00:00:00 UTC 2004
Tissue transglutaminase is a multifunctional BH3-only protein.
The Journal of biological chemistry
Rodolfo C,Mormone E,Matarrese P,Ciccosanti F,Farrace MG,Garofano E,Piredda L,Fimia GM,Malorni W,Piacentini M
A21348 was used in western blot to investigate the interaction of tissue transglutaminase with proteins that regulate apoptosis
Fri Dec 24 00:00:00 UTC 2004
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death.
The Journal of biological chemistry
Cao J,Semenova MM,Solovyan VT,Han J,Coffey ET,Courtney MJ
A21348 was used in western blot to investigate the signaling pathways that regulate cerebellar granule neuron cell death
Fri Aug 20 00:00:00 UTC 2004
C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway.
Journal of immunology (Baltimore, Md. : 1950)
Soane L,Cho HJ,Niculescu F,Rus H,Shin ML
A21348 was used in western blot to study protection of oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway due to C5b-9 terminal complement complex
Wed Aug 15 00:00:00 UTC 2001
Akt regulates cell survival and apoptosis at a postmitochondrial level.
The Journal of cell biology
Zhou H,Li XM,Meinkoth J,Pittman RN
A21348 was used in western blot to elucidate how Akt or Bcl-2 inhibit apoptosis of hybrid motor neuron 1 cells
Mon Oct 30 00:00:00 UTC 2000
Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
Journal of neurochemistry
Wagenknecht B,Hermisson M,Groscurth P,Liston P,Krammer PH,Weller M
A21348 was used in western blot to elucidate how proteasome inhibitors induce apoptosis in human malignant glioma cells
Fri Dec 01 00:00:00 UTC 2000
Interaction of mammalian mitochondrial ribosomes with the inner membrane.
The Journal of biological chemistry
Liu M,Spremulli L
A21348 was used in ELISA to test if mitochondrial protein biosynthesis occurs on ribosomes associated with the inner membrane
Fri Sep 22 00:00:00 UTC 2000
Inhibition of c-Myc expression sensitizes hepatocytes to tumor necrosis factor-induced apoptosis and necrosis.
The Journal of biological chemistry
Liu H,Lo CR,Jones BE,Pradhan Z,Srinivasan A,Valentino KL,Stockert RJ,Czaja MJ
A21348 was used in western blot to examine the function of c-Myc in hepatocyte sensitivity to tumor necrosis factor
Fri Dec 22 00:00:00 UTC 2000
Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death.
The Journal of biological chemistry
Atlante A,Calissano P,Bobba A,Azzariti A,Marra E,Passarella S
A21348 was used in western blot to elucidate how reactive oxygen species and cytochrome c contribute to neurotoxicity
Fri Nov 24 00:00:00 UTC 2000
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Cell
Wu Z,Puigserver P,Andersson U,Zhang C,Adelmant G,Mootha V,Troy A,Cinti S,Lowell B,Scarpulla RC,Spiegelman BM
A21348 was used in western blot to report that PGC-1 stimulates mitochondrial biogenesis and respiration in muscle cells via uncoupling protein 2 and nuclear respiratory factors
Fri Jul 09 00:00:00 UTC 1999
Biochemical, genetic and immunoblot analyses of 17 patients with an isolated cytochrome c oxidase deficiency.
Biochimica et biophysica acta
von Kleist-Retzow JC,Vial E,Chantrel-Groussard K,Rötig A,Munnich A,Rustin P,Taanman JW
A21348 was used in western blot to characterize patients with cytochrome c oxidase deficiency
Mon Sep 20 00:00:00 UTC 1999
Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism.
The Journal of biological chemistry
Tang D,Lahti JM,Grenet J,Kidd VJ
A21348 was used in western blot to elucidate the mechanisms that regulate cycloheximide-induced apoptosis
Fri Mar 12 00:00:00 UTC 1999
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.
Cell
Luo X,Budihardjo I,Zou H,Slaughter C,Wang X
A21348 was used in western blot to show that Bid relays an apoptotic signal from the cell surface to mitochondria
Fri Aug 21 00:00:00 UTC 1998
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.
Cell
Vander Heiden MG,Chandel NS,Williamson EK,Schumacker PT,Thompson CB
A21348 was used in flow cytometry and western blot to propose that Bcl-xL promotes cell survival by regulating the electrical and osmotic homeostasis of mitochondria
Fri Nov 28 00:00:00 UTC 1997
Molecular mechanisms in mitochondrial DNA depletion syndrome.
Human molecular genetics
Taanman JW,Bodnar AG,Cooper JM,Morris AA,Clayton PT,Leonard JV,Schapira AH
A21348 was used in western blot to characterize a child with mitochondrial DNA depletion in the liver and skeletal muscles
Sun Jun 01 00:00:00 UTC 1997
Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells.
Methods in enzymology
Capaldi RA,Marusich MF,Taanman JW
A21348 was used in western blot to Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells
Mon Apr 01 00:00:00 UTC 1996
Complexity and tissue specificity of the mitochondrial respiratory chain.
Journal of bioenergetics and biomembranes
Capaldi RA,Halphen DG,Zhang YZ,Yanamura W
A21348 was used in immunohistochemistry to review and discuss the mitochondrial respiratory chain
Wed Jun 01 00:00:00 UTC 1988
