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产品信息
PA5-76990
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human PDCD6.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720717
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
An increased intracellular Ca2+ concentration induces apoptotic cell death. Transiently elevated Ca2+ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (for apoptosis-linked gene 2) is a Ca2+ -binding protein that participates in regulatory events occuring late in the apoptotic program and where several death signals converge. ALG-2 is a protein expressed in normal brain, and to a greater extent in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, which includes Calpain small subunits sorcin and Grancalcin.
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生物信息学
蛋白别名: ALG-2; ALG-257; Apoptosis-linked gene 2 protein; Apoptosis-linked gene 2 protein homolog; PMP41; probable calcium-binding protein ALG-2; Programmed cell death protein 6
基因别名: ALG-2; ALG2; AV299538; MA-3; PDCD6; PEF1B; PS2
UniProt ID: (Human) O75340, (Rat) G3V7W1, (Mouse) P12815
Entrez Gene ID: (Human) 10016, (Rat) 308061, (Mouse) 18570
calcium-dependent cysteine-type endopeptidase activity
calcium ion binding
protein binding
identical protein binding
protein homodimerization activity
protein anchor
protein dimerization activity
calcium-dependent protein binding
binding, bridging
metal ion binding
actin or actin-binding cytoskeletal protein
angiogenesis
positive regulation of endothelial cell proliferation
proteolysis
intracellular protein transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of endothelial cell migration
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
cellular response to heat
vascular endothelial growth factor receptor-2 signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of angiogenesis
response to calcium ion
negative regulation of protein kinase B signaling
apoptotic signaling pathway
apoptotic process
