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产品信息
PA5-36113
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 708-763 of human PKD1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553375
产品详细信息
This antibody detects endogenous protein at a molecular weight of 90-140 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3
基因别名: 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3; RGD1308054
UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2
Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Rat) 313834, (Mouse) 75292
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
kinase activity
identical protein binding
metal ion binding
protein kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
angiogenesis
positive regulation of endothelial cell proliferation
protein phosphorylation
apoptotic process
inflammatory response
Golgi organization
signal transduction
integrin-mediated signaling pathway
Ras protein signal transduction
cell proliferation
positive regulation of endothelial cell migration
regulation of keratinocyte proliferation
positive regulation of neuron projection development
peptidyl-serine phosphorylation
sphingolipid biosynthetic process
regulation of protein stability
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
cellular response to oxidative stress
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of blood vessel endothelial cell migration
innate immune response
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
Golgi vesicle transport
positive regulation of NF-kappaB transcription factor activity
regulation of release of sequestered calcium ion into cytosol
negative regulation of cell death
protein kinase D signaling
positive regulation of histone deacetylase activity
positive regulation of endothelial cell chemotaxis
regulation of integrin-mediated signaling pathway
adaptive immune response
cell adhesion
cell death
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-8 production
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of cell adhesion
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
endothelial tube morphogenesis
positive regulation of ERK1 and ERK2 cascade
mitophagy in response to mitochondrial depolarization
positive regulation of intracellular signal transduction
positive regulation of DNA biosynthetic process
protein kinase C-activating G-protein coupled receptor signaling pathway
immune system process
nervous system development
phosphorylation
cell differentiation
