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PIAS1/PIAS2 Antibody (MA5-38199) in IHC (P)
Immunohistochemistry analysis of PIAS1/PIAS2 in paraffin-embedded human appendix. Samples were incubated with PIAS1/PIAS2 Monoclonal antibody (Product # MA5-38199) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-38199
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1690
抗原
A synthetic peptide corresponding to a sequence within amino acids 552-651 of human PIAS1+PIAS2 (O75925)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898116
产品详细信息
Positive Samples: HepG2, Mouse brain
Immunogen sequence: DNQHYNTSLL AAAAAAVSDD QDLLHSSRFF PYTSSQMFLD QLSAGGSTSL PTTNGSSSGS NSSLVSSNSL RESHSHTVTN RSSTDTASIF GIIPDIISLD
靶标信息
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Androgen receptor-interacting protein 3; AR interacting protein; ARIP3; DAB2-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; DIP; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS1; E3 SUMO-protein transferase PIAS2; GBP; Gu-binding protein; Miz1; Msx-interacting zinc finger protein; Msx-interacting-zinc finger; Msx-interacting-zinc finger protein; PIAS-NY protein; PIASxalpha6; Protein inhibitor of activated STAT protein 1; Protein inhibitor of activated STAT x; protein inhibitor of activated STAT-1; Protein inhibitor of activated STAT2; RING-type E3 ubiquitin transferase PIAS1; RING-type E3 ubiquitin transferase PIAS2; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; zinc finger, MIZ-type containing 4
基因别名: 2900068C24Rik; 6330408K17Rik; AI462206; ARIP3; AU018068; DDXBP1; Dib; DIP; GBP; GU/RH-II; MIZ; MIZ1; PIAS1; PIAS2; PIASX; PIASX-ALPHA; PIASX-BETA; PIASxalpha; PIASxb; PIASxbeta; SIZ2; ZMIZ3; ZMIZ4
UniProt ID: (Human) O75925, (Human) O75928, (Mouse) O88907, (Rat) Q6AZ28, (Mouse) Q8C5D8
Entrez Gene ID: (Human) 8554, (Human) 9063, (Mouse) 56469, (Rat) 300772, (Rat) 83422, (Mouse) 17344
DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
transcription factor binding
zinc ion binding
ligase activity
SUMO transferase activity
enzyme binding
ubiquitin protein ligase binding
androgen receptor binding
SUMO ligase activity
protein C-terminus binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
protein domain specific binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
estrogen receptor binding
glucocorticoid receptor binding
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
metabolic process
response to organic substance
protein sumoylation
androgen receptor signaling pathway
response to testosterone
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of dendrite morphogenesis
regulation of androgen receptor signaling pathway
negative regulation of androgen receptor signaling pathway
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of smooth muscle cell differentiation
protein-DNA complex assembly
negative regulation of nucleic acid-templated transcription
regulation of interferon-gamma-mediated signaling pathway
