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PIGR Antibody (PA5-22096) in ICC/IF
PIGR Polyclonal Antibody detects PIGR protein by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PIGR stained by PIGR Polyclonal Antibody (Product # PA5-22096) diluted at 1:500. Blue: Fluoroshield with DAPI . Scale bar= 10 µm.
产品信息
PA5-22096
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 180 and 459 of PIGR (Uniprot ID#P01833)
偶联物
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11157655
产品详细信息
Recommended positive controls: Human milk.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids. The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein. The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hepatocellular carcinoma associated protein TB6; Hepatocellular carcinoma-associated protein TB6; PIgR; Poly Ig receptor; poly-Ig receptor; Polymeric immunoglobulin receptor; tb6
基因别名: PIGR
UniProt ID: (Human) P01833
Entrez Gene ID: (Human) 5284
