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PRL3 Antibody (PA5-96031) in IHC (P)
Immunohistochemistry analysis of PRL3 in paraffin-embedded human gastric cancer. Samples were incubated with PRL3 Polyclonal antibody (Product # PA5-96031) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-96031
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human PTP4A3 (NP_0090102)
偶联物
形式
Liquid
浓度
0.61 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807833
产品详细信息
Immunogen sequence: MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR KRRGAINSKQ LTYLEKYRPK QRLRFKDPHT HKTRCCVM; Positive Samples: K-562, 293T; Cellular Location: Cell membrane, Early endosome
靶标信息
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HPRL-3; potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; Protein tyrosine phosphatase type IVA 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3
基因别名: AV088979; pPtp4a3; PRL-3; PRL-R; PRL3; PTP4A3
UniProt ID: (Human) O75365, (Mouse) Q9D658
Entrez Gene ID: (Human) 11156, (Mouse) 19245
