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产品信息
H00005734-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PTGER4 (NP_000949.1, 1 a.a. approximately 488 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSTPGVNSSA SLSPDRLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG LAVTDLLGTL LVSPVTIATY MKGQWPGGQP LCEYSTFILL FFSLSGLSII CAMSVERYLA INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGS SRLQYPDTWC FIDWTTNVTA HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAASVASRG HPAASPALPR LSDFRRRRSF RRIAGAEIQM VILLIATSLV VLICSIPLVV RVFVNQLYQP SLEREVSKNP DLQAIRIASV NPILDPWIYI LLRKTVLSKA IEKIKCLFCR IGGSRRERSG QHCSDSQRTS SAMSGHSRSF ISRELKEISS TSQTLLPDLS LPDLSENGLG GRNLLPGVPG MGLAQEDTTS LRTLRISETS DSSQGQDSES VLLVDEAGGS GRAGPAPKGS SLQVTFPSET LNLSEKCI
靶标信息
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EP1; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor
基因别名: EP4; EP4R; PTGER2; PTGER4
UniProt ID: (Human) P35408
Entrez Gene ID: (Human) 5734
negative regulation of peptide secretion
immune response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JNK cascade
female pregnancy
positive regulation of cell proliferation
response to mechanical stimulus
positive regulation of gene expression
negative regulation of hydrogen peroxide metabolic process
regulation of circadian sleep/wake cycle, wakefulness
positive regulation of smooth muscle cell migration
positive regulation of cAMP biosynthetic process
response to lipopolysaccharide
response to progesterone
positive regulation of interleukin-8 production
negative regulation of integrin activation
positive regulation of urine volume
positive regulation of renal sodium excretion
T-helper cell differentiation
negative regulation of circadian sleep/wake cycle, REM sleep
chemokinesis
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
response to amino acid
positive regulation of osteoblast differentiation
positive regulation of bone resorption
positive regulation of cell adhesion
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of cytokine secretion
negative regulation of interleukin-1 alpha secretion
positive regulation of cytokine secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of stress fiber assembly
negative regulation of nitric-oxide synthase biosynthetic process
maternal process involved in parturition
bone development
positive regulation of mucus secretion
ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to prostaglandin E stimulus
positive regulation of wound healing
ductus arteriosus closure
positive regulation of hyaluronan biosynthetic process
response to salt
negative regulation of ductus arteriosus closure
negative regulation of small intestine smooth muscle contraction
positive regulation of calcitonin secretion
positive regulation of chemokinesis
positive regulation of matrix metallopeptidase secretion
negative regulation of tumor necrosis factor secretion
negative regulation of endothelin secretion
positive regulation of substance P secretion, neurotransmission
response to water-immersion restraint stress
positive regulation of antral ovarian follicle growth
positive regulation of neutrophil extravasation
negative regulation of eosinophil extravasation
positive regulation of interleukin-10 secretion
