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产品信息
5741-MSM3-P0
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
PTH/1173
抗原
A recombinant fragment around aa 32-115 of human mature-PTH-polypeptide.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness.
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生物信息学
蛋白别名: Parathormone; Parathyrin; Parathyroid hormone; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone; PTH
基因别名: PTH; PTH1
UniProt ID: (Human) P01270
Entrez Gene ID: (Human) 5741
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
cell-cell signaling
hormone-mediated apoptotic signaling pathway
positive regulation of signal transduction
response to lead ion
regulation of gene expression
positive regulation of bone mineralization
positive regulation of cAMP biosynthetic process
response to vitamin D
cellular macromolecule biosynthetic process
response to drug
bone resorption
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
cAMP metabolic process
positive regulation of glucose import
response to cadmium ion
homeostasis of number of cells within a tissue
response to parathyroid hormone
response to fibroblast growth factor
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
positive regulation of osteoclast proliferation
