Invitrogen

Phospho-CDK1 (Tyr15) Polyclonal Antibody

查看其他2个CDK1抗体

产品信息

PA5-17873

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫沉淀 (IP)

1:100

-

产品规格

种属反应

Fruit fly, Human, Mouse, Non-human primate, Rat, Xenopus, Yeast

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pTyr15 of human cdc2

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

38 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10974325

产品详细信息

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with CDK4, CDK6 or CDK7.

靶标信息

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: 3'-5' exodeoxyribonuclease; ABL1; cdc2; cdc2 kinase; CDK1; CDK1-A; Cdk1-PA; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control; Cell division control protein 2 homolog; Cell division control protein 2 homolog 1; Cell division control protein 2-A; cell division cycle 2 homolog A; cell division cycle 2 like; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; Cell division protein kinase 1; Cell division protein kinase 1-A; CG5363-PA; cyclin dependent kinase; cyclin-dependent kinase; Cyclin-dependent kinase 1; Cyclin-dependent kinase 1-A; DKFZp686L20222; DNA polymerase delta catalytic subunit; DNA polymerase III; KCIP-1; maturation-promoting factor; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; p34 protein kinase 1; Pol3p; Protein 1054; protein 2

查看更多收起

基因别名: cdc; 5363; cdc-2; CDC2; cdc2-a; CDC28A; Cdc2a; cdc2Dm; cdc2x1.1; CDCDm; Cdk-1; CDK1; cdk1-a; cdk1-b; CDK1/CDC2; CDKN1; CG5363; D2366; Dcdc2; dCdk1; Dm cdc2; DmCdc2; DmCdk1; Dmel\CG5363; Dmel_CG5363; group 4; HPR6; l(2)31Eh; MPF; p34; P34CDC2; POL3; PSTAIR; TEX1; xcdc2; XELAEV_18036802mg; YDL102W

查看更多收起

UniProt ID: (Human) P06493, (Rat) P39951, (Fruit fly) P23572, (Mouse) P11440, (Baker's yeast) P15436, (Xenopus) P35567

查看更多收起

Entrez Gene ID: (Human) 983, (Rat) 54237, (Fruit fly) 34411, (Mouse) 12534, (Baker's yeast) 851456, (Xenopus) 380246

查看更多收起

protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding RNA polymerase II carboxy-terminal domain kinase activity cyclin binding Hsp70 protein binding histone kinase activity kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups nucleic acid binding DNA binding DNA-directed DNA polymerase activity nuclease activity exonuclease activity 3'-5'-exodeoxyribonuclease activity single-stranded DNA 3'-5' exodeoxyribonuclease activity nucleotidyltransferase activity hydrolase activity metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding

参与通路

mitotic cell cycle protein complex assembly protein phosphorylation apoptotic process mitotic nuclear division mitotic G2 DNA damage checkpoint cell aging response to toxic substance response to organonitrogen compound positive regulation of gene expression response to organic cyclic compound response to amine response to activity histone phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation chromosome condensation epithelial cell differentiation organ regeneration positive regulation of protein import into nucleus, translocation protein localization to kinetochore response to drug response to hydrogen peroxide negative regulation of apoptotic process response to ethanol positive regulation of DNA replication positive regulation of mitotic cell cycle response to cadmium ion response to copper ion response to axon injury cell division ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cellular response to hydrogen peroxide mitotic S phase nucleobase-containing compound metabolic process DNA replication RNA-dependent DNA biosynthetic process base-excision repair, gap-filling nucleotide-excision repair, DNA gap filling regulation of mitotic cell cycle DNA replication, removal of RNA primer DNA replication proofreading DNA-dependent DNA replication maintenance of fidelity nucleic acid phosphodiester bond hydrolysis G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle cellular response to DNA damage stimulus male meiosis male meiosis I spermatogenesis spermatogonial cell division meiotic G2/MI transition neurogenesis ovarian follicle cell development regulation of protein localization mitotic G2/M transition checkpoint germarium-derived cystoblast division regulation of cell cycle asymmetric neuroblast division phosphorylation of RNA polymerase II C-terminal domain cell cycle phosphorylation regulation of transcription involved in G1/S transition of mitotic cell cycle activation of MAPK activity microtubule cytoskeleton organization DNA repair DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic nuclear envelope disassembly centrosome cycle pronuclear fusion regulation of Schwann cell differentiation cell migration anaphase-promoting complex-dependent catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of embryonic development negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Golgi disassembly positive regulation of protein localization to nucleus