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Phospho-Naked2 (Tyr247) Antibody (PA5-105098) in ICC/IF
Immunofluorescent analysis of Phospho-Naked2 (Tyr247) in HepG2 cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Naked2 (Tyr247) polyclonal antibody (Product # PA5-105098) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor... View More
产品信息
PA5-105098
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NKD2(Accession Q969F2), corresponding to amino acid residues around phosphorylated Tyr247.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816571
产品详细信息
Antibody detects endogenous levels of NAKED2 only when phosphorylated at Tyr247.
靶标信息
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dvl-binding protein NKD2; hNkd2; mNkd2; naked cuticle 1 homolog; naked cuticle 2 homolog; naked cuticle-2; Naked-2; Protein naked cuticle homolog 2
基因别名: 2210403L10Rik; AW212591; Naked2; NKD2
UniProt ID: (Human) Q969F2, (Mouse) Q8VE28
Entrez Gene ID: (Human) 85409, (Rat) 308068, (Mouse) 72293
exocytosis
positive regulation of protein processing
Wnt signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Golgi vesicle fusion to target membrane
protein targeting to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
transport
